间充质干细胞对造血干细胞移植中移植物抗宿主病的防治机制  

Mechanisms of mesenchymal stem cells＇ effect on the graft-versus-host disease after hematopoietic stem cell transplantation

作　　者：宁雪(综述)[1] 鞠秀丽(审校)[1] 

机构地区：[1]山东大学齐鲁医院儿童医疗中心山东大学齐鲁医院低温医学研究室,济南250012

出　　处：《国际儿科学杂志》2011年第5期503-505,共3页International Journal of Pediatrics

基　　金：山东省科技发展计划项目（2009GG10002027）

摘　　要：异基因造血干细胞移植是治疗多种血液系统恶性疾病以及一些自身免疫性和遗传性疾病的有效手段，而移植物抗宿主病（graft—versus—host disease，GVHD）是异基因造血干细胞移植中最常见的并发症，由于GVHD的发生机制十分复杂，目前还没有完全可靠的治疗手段。近年来，间充质干细胞（mesenchymal stem cells，MSC）的免疫调节作用逐渐成为研究的热点，已经有相关研究利用MSC的这一特性防治造血干细胞移植后的GVHD，同时研究发现MSC与造血干细胞共移植也可以促进造血干细胞的植入。Allogeneic hematopoietic stem cell transplantation（alloHSCT） is a potentially curative therapy for patients with hematological malignant disease, autoimmune disease or hereditary disease. However, graftversus-host disease （GVHD）, which is one of the most serious complications, influences the prognosis of alloHSCT. Mechanisms of GVHD is so complicated that there is still no perfect way to treat the patients at present. Recently, mesenchymal stem cells （MSC）become new hotspots because of their immunomodulatory properties and potential to suppress alloreactive T cell responses. Animal experiments showed that MSC were effective during the prevention and treatment of GVHD. This paper is to summarize the acting mechanism of MSC＇ effect on the prevention and treatment of GVHD after alloHSCT.

关 键 词：间充质干细胞 移植物抗宿主病 造血干细胞移植 免疫调节 

分 类 号：R457.7[医药卫生—治疗学]