江苏省新甲型H1N1流感疫苗免疫后抗体水平变化趋势研究  

Study on tendency of antibodies levels of influenza A(H1N1) vaccine inoculated population in Jiangsu Province

作　　者：秦圆方[1] 祁贤[1] 李亮[1] 祖荣强[1] 吴斌[1] 付建光[1] 王慎骄[1] 田华[1] 嵇红[1] 霍翔[1] 汤奋扬[1] 朱凤才[1] 汪华[1] 

机构地区：[1]江苏省疾病预防控制中心,江苏南京210009

出　　处：《中华疾病控制杂志》2011年第9期773-776,共4页Chinese Journal of Disease Control & Prevention

摘　　要：目的了解新甲型H1N1流感疫苗免疫前后人群抗体水平动态变化情况。方法随机选取部分疫苗接种人群为受试者,微量半加敏血凝抑制实验检测免疫前、免疫后1个月与免疫后3个月的血清抗体水平,计算抗体阳性率与抗体几何平均滴度（GMT）,并进行统计学分析。结果免疫前、免疫后1个月与3个月抗体阳性率分别为13.64%（9.58%-18.61%）、83.63%（78.15%-88.20%）、77.06%（71.09%-82.32%）,GMT分别为9.36（8.30-10.56）、122.53（100.29-149.70）、96.07（77.85-118.54）。免疫前与免疫后1个月、3个月后相比,抗体阳性率与GMT差异均有统计学意义。免疫后1个月与免疫后3个月两者差异均无统计学意义。结论本研究所用甲型H1N1流感病毒裂解疫苗免疫后抗体水平明显升高,且维持时间较长。Objective To investigate the developing tendency of antibodies levels of the type A （H1N1） influenza vaccine inoculated people. Methods Observation objects were randomly selected from people vaccinated with influenza A （H1N1） vaccine, and their antibody titers were tested with Hemagglutination inhibition （HI） assays before immunization, 1 month and 3 month after it respectively. Antibody positive rates of influenza A （H1N1） virus and their Geometric mean titer （GMT） of HI antibody were estimated. Results The seropositive rates at these 3 time spots （before the vacci- nation, 1 month and 3 month after it） were 13.64% （9.58%-18.61%）, 83.63% （78.15%-88.20%）, 77.06% （71.09 % -82.32 % ） and GMT were 9.36（ 8.30-10.56 ）, 122.53 （100.29-149.70 ）, 96.07 （77.85- 118.54 ） respectively. The antibody positive rates＇ level and GMT were significantly higher than that of preimmunization, while differences between 1 and 3 month post-immunization antibody levels and GMT had no statistical significance. Conclusions The influenza A （H1N1） split-virion vaccine used in the present study could induce a high and persistent antibody level.

关 键 词：流感病毒A型 H1N1亚型 流感疫苗 抗体 

分 类 号：R181.1[医药卫生—流行病学]