结合药效学指标正交优选复方止呕颗粒提取工艺  

Optimizing Extraction Process of Fufang Zhiou Granules by Orthogonal Test with Pharmacodynamic Index

作　　者：冯果[1] 刘文[1] 张永萍[1] 马雯雯[2] 冯泳[1] 

机构地区：[1]贵阳中医学院,贵阳550002 [2]中国人民解放军第一医院药剂科,兰州730030

出　　处：《中国实验方剂学杂志》2011年第18期32-34,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：贵州省中药现代化专项(黔科合社字[2008]5025号)

摘　　要：目的:筛选复方止呕颗粒的最佳提取工艺条件。方法:采用正交设计法和药效学实验,以有效成分6-姜酚和止呕效果作为评价指标,对复方止呕颗粒最佳提取工艺条件进行优选。结果:最佳提取工艺条件为加9倍量水,提取3次,每次1h。最佳提取工艺条件验证结果满意。结论:用正交设计法结合药效学指标优选复方止呕颗粒提取工艺条件,具有药物有效成分与功能主治密切结合的特点,优选出的最佳提取工艺稳定、可行、重复性好。Objective：To optimize extraction process conditions of Fufang Zhiou Granules.Method：Optimized extraction process conditions of Fufang Zhiou granule by orthogonal design and pharmacodynamics test,6-gingerol and vomiting results as evaluated indexes.Result：Optimum extraction conditions were as follows：extracted three times with 9 times the amount of water for 1 h every time.Optimum extraction conditions were verified with satisfactory results.Conclusion：Optimized the extraction conditions by orthogonal design and pharmacodynamic test with the characteristics of active ingredients and indications combined closely.The optimized extraction process was stable,reliable,reproducible.

关 键 词：复方止呕颗粒 正交设计 药效学指标 提取工艺 

分 类 号：R283.6[医药卫生—中药学]