GC法同时测定冠心舒通胶囊中丁香酚、龙脑和异龙脑  

Determination Eugenol,Borneol and Isoborneol of Guanxin Shutong Capsule by Gas Chromatography

作　　者：刘峰 马久太 单娜 卢新义 党艳妮 杨东花[2] 

机构地区：[1]陕西步长制药有限公司,陕西咸阳712000 [2]陕西中医学院,陕西咸阳712046

出　　处：《中国实验方剂学杂志》2011年第18期56-59,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：十二五国家重大新药创制专项(2011ZX09401-308);陕西省2008年"13115"科技创新工程重大科技产业化项目(2008ZDCY-23)

摘　　要：目的:建立同时测定冠心舒通胶囊中丁香酚、龙脑和异龙脑含量的气相色谱测定方法。方法:采用气相色谱法,聚乙二醇20 000为固定相,涂布浓度为10%,载气氮气,氢火焰离子化检测器。结果:丁香酚在2.025 6～50.640 0μg(r=0.999 5,n=6),龙脑在29.90～104.65μg(r=0.999 0,n=6),异龙脑在30.2～105.7μg(r=0.999 4,n=6)线性关系良好,平均加样回收率分别为100.95%,RSD 0.72%(n=6),99.72%,RSD 0.38%(n=6),100.47%,RSD 1.11%(n=6)。结论:所建立的方法可同时对丁香酚、龙脑和异龙脑进行含量测定,准确、灵敏、重现性好,可用于冠心舒通胶囊的质量控制。Objective：The GC method was established for determination simulataneo of eugenol,borneol and isoborneol of Guanxin Shutong capsule.Method：The stationary phase of capillary column is polyethyleneglycol 20 000,with 10% coating.Carrier gas is nitrogen,detector is Flame Ionization Detector（FID）.Result：The standard curve was linear within the concentration range of 2.025 6-50.640 0 μg（r=0.999 0） for eugenol,29.9-104.65 μg（r=0.999 5） for borneol.and 30.2-105.7 μg（r=0.999 4） for isoborneol The average recovery of eugenol,borneol and isoborneol was 100.95%（n=6,RSD 0.72%）,99.72%（n=6,RSD 0.38%） and 100.47%（n=6,RSD 1.11%）.Conclusion：The contents of eugenol,borneol and isoborneol in Guanxin Shutong capsule were determined in the first time.The method is simple,stability and feasible,controllable strong,which can beused to determinate the content of eugenol,borneol and isoborneol of Guanxin Shutong capsule.

关 键 词：冠心舒通胶囊 丁香酚 龙脑 异龙脑 气相色谱法 

分 类 号：R284.1[医药卫生—中药学]