原子荧光光谱法检测牛黄解毒片及其拆方可溶性砷的含量  

Determination of Soluble Arsenic in Niuhuang Jiedu Tablets and Its Disassembled Presciption by AFS

作　　者：董菊[1] 陈辉[2] 吴娟[1] 王明艳[1] 詹瑧[1] 

机构地区：[1]南京中医药大学基础医学院,南京210046 [2]南京市疾病预防控制中心,南京210003

出　　处：《中国实验方剂学杂志》2011年第18期67-70,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：江苏省高校研究生科研创新计划项目(2010);江苏省中医药药效与安全评价重点实验室开放课题(T09019)

摘　　要：目的:探讨牛黄解毒片配伍对有毒中药雄黄是否具有减毒作用及其可能减毒药味。方法:设立牛黄解毒片全方及其不同拆方组,分别用人工胃液或人工肠液处理,然后采用原子荧光光谱法测定并比较不同组可溶性砷的含量。结果:人工胃液或人工肠液处理后,牛黄解毒片全方组可溶性砷含量明显低于单味雄黄组(P<0.01);牛黄解毒片全方去甘草、黄芩、大黄组可溶性砷含量明显高于牛黄解毒片全方组(P<0.01)。结论:牛黄解毒片全方配伍对雄黄有减毒作用,并且甘草、黄芩、大黄是减毒的可能药味。Objective：To explore whether the compatibility of Niuhuang Jiedu tablets could reduce the toxicity of realgar,and which may be the possible herbal medicines that could reduce toxicity in the Niuhuang Jiedu tablets prescription.Method：Different groups about Niuhuang Jiedu Tablets and its disassembled prescription were arranged,treated with artificial gastric juice or artificial intestine juice,and then atom fluorescence spectrophotometry（AFS） was used to detect the content of soluble arsenic in the different groups samples.Result：The content of soluble arsenic in the whole prescription was significant lower than that in the single realgar（P0.01）.The content of soluble arsenic in the whole prescription except for Gancao,Huangqin and Dahuang was significant higher than that in the whole prescription（P0.01）.Conclusions：The compatibility for Niuhuang Jiedu tablets could reduce the toxicity of realgar,and Gancao,Huangqin and Dahuang may be the possible herbal medicines that could reduce toxicity.

关 键 词：原子荧光光谱法 牛黄解毒片 拆方 雄黄 可溶性砷 

分 类 号：R284.1[医药卫生—中药学]