抗毒补心胶囊对急性心肌缺血模型大鼠的心肌保护作用  

Experimental Study on the Treatment of Kangdu Buxin Capsule on Model Rats with Acute Myocardial Ischemia

作　　者：王贺军[1] 吕立勋[2] 马会霞[3] 许晴[3] 包巨太[3] 

机构地区：[1]遵化市人民医院消化内科,河北唐山064200 [2]河北联合大学药学院,河北唐山063000 [3]河北联合大学中医学院,河北唐山063000

出　　处：《中国实验方剂学杂志》2011年第18期218-220,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：唐山市科技局重点支持项目(08360202A)

摘　　要：目的:研究抗毒补心胶囊对急性心肌缺血模型大鼠的心肌保护作用并探讨其作用机制。方法:Wistar大鼠72只,随机分成假手术组、模型组、阳性对照组、抗毒补心胶囊低,中,高剂量含生药0.4,0.8,1.6 g.kg-1组,连续预防口服给药14d,采用冠状动脉结扎制备急性心肌缺血大鼠模型,观察抗毒补心胶囊对模型大鼠血清中肌酸磷酸激酶(CK)、乳酸脱氢酶(LDH)、丙二醛(MDA)、超氧化物歧化酶(SOD)的影响。结果:抗毒补心胶囊能明显降低心肌缺血模型大鼠血清中CK,LDH活性和MDA含量以及明显提高血清中SOD活性。结论:抗毒补心胶囊对冠状动脉结扎制备的心肌缺血大鼠模型有较好的心肌保护作用。Objective：To study protection on myocardium and mechanism of Kangdu Buxin Capsule on model rats with acute myocardial ischemia.Method：Seventy two Wistar rats were randomly divided into sham operation group,model group,positive group,Kangdu Buxin Capsule low,medium and high dose groups,each group orally administered 14 days.Then,model rats with acute myocardial ischemia were prepared by coronary artery ligation.The influences on the content of creatine kinase（CK）,lactate dehydrogenase（LDH）,malonaldehyde（MDA）,superoxide dismutase（SOD） were observed.Result：Kangdu Buxin Capsule significantly reduced the content of CK,MDA,LDH in serum of model rats with acute myocardial ischemia.Kangdu Buxin Capsule significantly improved the content of SOD in serum of model rats.Conclusion：Kangdu Buxin Capsule has a protective effect on model rats with acute myocardial ischemia prepared by coronary artery ligation.

关 键 词：抗毒补心胶囊 急性心肌缺血 心肌保护 

分 类 号：R285.5[医药卫生—中药学]