菟丝子多糖改善糖尿病大鼠糖脂代谢作用  

Effects of Cuscuta chinensis Polysaccharide on Glucose-lipid Metabolism in Diabetic Rats

作　　者：徐先祥[1] 李道中[2] 彭代银[3] 张睿[3] 

机构地区：[1]华侨大学分子药物学研究所,福建泉州362021 [2]安徽省桐城市人民医院,安徽桐城231400 [3]安徽中医学院药学院,合肥230038

出　　处：《中国实验方剂学杂志》2011年第18期232-234,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:研究菟丝子多糖对链脲佐菌素(STZ)致糖尿病大鼠糖脂代谢的影响。方法:大鼠尾静脉注射50 mg.kg-1STZ制作糖尿病模型,10 d后以空腹血糖>11.1 mmol.L-1者作为糖尿病大鼠,每组8只,随机分为模型组,菟丝子多糖400,200,100 mg.kg-1剂量组和阿卡波糖15 mg.kg-1阳性对照组,另设正常对照组。各组大鼠ig给药(或生理盐水),连续给药15d,测定大鼠体重,空腹血糖,糖化血清蛋白,胰岛素和血脂水平等指标,观察菟丝子多糖对糖尿病大鼠糖脂代谢的影响。结果:模型组大鼠体重显著下降(P<0.01),空腹血糖、糖化血清蛋白、胆固醇(CHO),甘油三酯(TG)较正常对照组显著升高(P<0.01,P<0.01,P<0.05,P<0.01),同时胰岛素水平显著降低(P<0.01)。与模型组比较,菟丝子多糖中、高剂量组大鼠体重显著增加(P<0.05,P<0.01),同时空腹血糖、糖化血清蛋白水平显著下降(P<0.01,P<0.01;P<0.01,P<0.05);菟丝子多糖高剂量组CHO水平显著下降(P<0.05),低、中、高剂量组TG水平均显著降低(P<0.01,P<0.05,P<0.01)。菟丝子多糖各剂量组胰岛素水平上升无统计学意义。结论:菟丝子多糖能改善实验性糖尿病大鼠糖脂代谢。Objective：To study the effect of Cuscuta chinensis polysaccharide（CCP） on glucose-lipid metabolism in diabetic rats induced by streptozotocin.Method：The rat diabetic model was established by 50 mg·kg-1 streptozotocin iv,10 days later the rats with fasting blood glucose beyond 11.1 mmol·L-1 were selected as diabetic rats.Experimental groups（n=8,each） included model,CCP（400,200,100 mg·kg-1）,acarbose 15 mg·kg-1,and another normal control group was also setup.After ig treatment for 15 days,body weight,fasting blood glucose,glycosylated serum protein,insulin,blood lipid level in rats were measured to evaluate the effect of CCP.Result：In model group,body weight was significantly reduced（P0.01）and levels of fasting blood glucose,glycosylated serum protein,CHO,TG were increased（P0.01 or P0.05）while insulin level was reduced（P0.01）,compared with those in the normal control.CCP 200,400 mg·kg-1 could significantly improve the weight loss of diabetic rats（P0.05,P0.01）,reduce fasting blood glucose and glycosylated serum protein（P0.01 or P0.05）,CCP 400 mg·kg-1 could significantly reduce CHO level（P0.05）.CCP 400,200,100 mg·kg-1 could significantly reduce TG level（P0.01 or P0.05）.No obvious effect of CCP on insulin level was observed.Conclusion：CCP could improve glucose-lipid metabolism for the experimental diabetic rats.

关 键 词：菟丝子多糖 糖尿病 糖脂代谢 

分 类 号：R285.5[医药卫生—中药学]