脱氧新羟曲霉酸产生菌2101的分类鉴别  

Identification of strain 2101 produced desoxyneohydroxyaspergillic acid

作　　者：苏静[1] 黄明玉[1] 张月琴[1] 余利岩[1] 刘伟[1] 姜威[1] 司书毅[1] 刘红宇[1] 

机构地区：[1]中国医学科学院北京协和医学院医药生物技术研究所,北京100050

出　　处：《中国抗生素杂志》2011年第9期659-661,共3页Chinese Journal of Antibiotics

基　　金：国家科技基础条件平台项目(编号2005DKA21203);"重大新药创制"科技重大专项项目(编号2009ZX09301-003;2009ZX09302-004)

摘　　要：从土壤中分离到一株真菌菌株2101,经鉴定该菌株发酵产物2101C是新结构化合物—脱氧新羟曲霉酸。通过rDNA-ITS和β-tubulin等基因序列的分析比对得到与Aspergillus属中相似性较高的3株菌株(Aspergillus persii、Aspergillus bridgeri和Aspergillus sclerotiorum),结合传统真菌分类方法与这三株菌进行比对,菌株2101定名为Aspergillus sclerotiorum。The train 2101 produced desoxyneohydroxyaspergillic acid was isolated from soil. Phylogenetic analysis of the rDNA-ITS and 13-tubulin gene sequence showed that strain 2101 was affiliated with the genus Aspergillus.It was related most closely to Aspergillus persii, Aspergillus bridgeri and Aspergillus sclerotiorum. According to the traditional classification,strain 2101 was identified to be Aspergillus sclerotiorum.

关 键 词：菌株2101 脱氧新羟曲霉酸 Β-TUBULIN rDNA—ITS 

分 类 号：R978.7[医药卫生—药品]