氟苯尼考新制剂  

Progress on New preparations of Florfenicol

作　　者：杨昆[1] 刘晗[1] 罗璋[1] 朱鑫[1] 杨亚[1] 陈小军[2] 李孝文[2] 孙志良[2] 

机构地区：[1]湖南农业大学东方科技学院,湖南长沙410128 [2]湖南农业大学动物医学院,湖南长沙410128

出　　处：《动物医学进展》2011年第8期108-111,共4页Progress In Veterinary Medicine

基　　金：湖南省大学生研究性学习和创新性实验计划资助项目;DFCXS201002

摘　　要：氟苯尼考又称氟甲砜霉素,是甲砜霉素的单氟衍生物。氟苯尼考由于具有抗菌谱广,吸收快,体内分布广,半衰期长,有效血药浓度时间长,无潜在的致再生障碍性贫血作用,也无致畸、致癌和致突变等缺点,而享有"最新一代兽药明星"的美誉,在兽医临床上发挥着重要作用。随着现代药学技术的进步,氟苯尼考的多种新制剂也相继被报道,文章综述了分别采用包合技术、固体分散技术、脂质体制备技术和自微乳化技术等制备的氟苯尼考新制剂,以期能为研发氟苯尼考高效、长效、速效的新制剂及其在兽医临床合理应用提供参考。Florfenicol is a synthetic, fluorinated analogue of chloramphenicol which lacks chloramphenieol＇s associated human health risk, besides with the features of broad spectrum antibacterial effect, rapid absorption, wide distribution in vivo, and extended half-life. Florfenicol is an antibiotic approved for veterinary use,and plays an important role in veterinary clinical application. With the development of modern pharmaceutic technologies, a series of new preparations of Florfenicol were reported. This article reviewed them with the aim of supplying guidelines for new preparations and veterinary clinical applications of Florfenicol.

关 键 词：氟苯尼考 制剂 

分 类 号：S859.796[农业科学—临床兽医学]