乳头溢液中癌抗原125测定在乳腺癌诊断中的意义  

Significance of Carcinoembryonic Antigen 125 Detection of the Nipple Discharge in the Diagnosis of Breast Cancer

作　　者：周新颖 郭桂华 尹淑新 

机构地区：[1]河北省迁安市人民医院肿瘤科,064400

出　　处：《中国全科医学》2011年第26期2987-2989,共3页Chinese General Practice

摘　　要：目的探讨乳头溢液中癌抗原(CA)125对早期乳腺癌的诊断意义。方法应用免疫化学发光法对148例乳头溢液患者(分为良性病变组和乳腺癌组)及正常分娩产妇40例(对照组)进行乳头溢液和血清中CA125水平的检测,同时检测乳头溢液中癌胚抗原(CEA)和CA153的水平,比较其有无差异。结果 3组受检者乳头溢液、血清中CA125水平比较,差异均有统计学意义(P<0.01)。各组受检者的乳头溢液中CA125、CEA、CA153的阳性率比较,差异均无统计学意义(P>0.05)。乳腺癌组乳头溢液CA125的阳性率与血清CA125阳性率比较,差异有统计学意义(P<0.01)。结论乳头溢液中CA125的检测是一种无损伤无痛苦的临床检测手段,其对乳腺癌的早期诊断具有一定的临床参考和实用价值。Objective To explore the significance of carcinoembryonic antigen （ CA125 ） in nipple discharge in the early diagnosis of breast cancer. Methods Chemiluminescent immunoassay method was applied in 148 patients with nipple dis- charge （divided into the benign and malignant group） and 40 delivery cases （the control group ） to detect the CA125 levels in nipple discharge and serum as well as carcinoembryonic antigen （ CEA ） and CA153 levels in nipple discharge. Results CA125 levels in the nipple discharge and the serum were significantly different among the 3 groups （ P 〈0.01 ） . CA125, CEA, and CA153 positive rates in nipple discharge of the 3 groups were not significantly different （P 〉 0. 05 ） . Positive rates of CA125 in the nipple discharge and in the serum showed statistical differences for the breast cancer group （ P 〈 0. 01 ） . Conclusion As non -invasive and painless as it is, CA125 testing of the nipple discharge is valuable in early diagnosis of breast cancer.

关 键 词：乳溢 抗原 肿瘤 乳腺肿瘤 诊断 

分 类 号：R655.8[医药卫生—外科学]