小儿原发性肠套叠血浆胃动素水平变化研究  

Changes of Plasma Motilin in Infant Primary Intussusception

作　　者：王永森[1] 白锡波[1] 姬汉书[1] 张庆峰[1] 冀向宁[1] 郭艳汝[1] 

机构地区：[1]河北省沧州市中心医院,061001

出　　处：《中国全科医学》2011年第26期2997-2998,共2页Chinese General Practice

基　　金：沧州市科学技术研究与发展指导计划(09ZD34)

摘　　要：目的探索原发性肠套叠患儿急性期及恢复期血浆胃动素水平的变化。方法采用放射免疫法检测原发性肠套叠患儿在发病当日(急性期)及发病后15 d(恢复期)的血浆胃动素水平,并与对照组比较,同时检测白细胞计数做相关性分析。结果原发性肠套叠患儿血浆胃动素水平急性期较正常儿显著升高,差异有统计学意义(P<0.01),并与白细胞计数呈正相关(P<0.01);恢复期迅速下降至正常水平,与对照组比较差异无统计学意义(P>0.05)。结论血浆胃动素水平在原发性肠套叠急性期的升高是继发于疾病本身或其诱因(病毒感染)等引发的免疫炎症反应,或继发于疾病急性期的应激反应、神经反射等因素,同时升高的胃动素又可能促进了肠套叠疾病的发生发展。Objective To explore the changes of plasma motilin levels in infant primary intussusceptions during the a- cute phase and the recovery phase. Methods Plasma motilin levels were detected via radioimmunoassay method in infants with primary intussusception both on the day of onset （acute phase） and 15 days after onset （recovery phase） and compared with those in normal controls. White blood cell counts were also obtained to carryout correlation analysis. Results Plasma motilin lev- els increased significantly during the acute phase in infants with primary intussusception （P 〈 O. 01 ）and were positively correla- ted with white blood cell counts （P 〈 O. 01 ） . Plasma motilin levels failed back to normal during the recovery phase, when no significant differences were observed when compared with normal controls （P 〉 0.05） . Conclusion Either as the consequence of inflammatory responses caused by the disease itself or the disease inducement （virus infecti^n）, or secondary to factors inclu- ding stress and nerve reflex during the acute phase, the increase of plasma motilin levels might play a role in the pathogenesis and development of the disease.

关 键 词：肠套叠 胃肠激素类 促胃动素 放射免疫测定 白细胞 

分 类 号：R725.743[医药卫生—儿科]