定喘汤对支气管哮喘大鼠气道重塑及嗜酸粒细胞的影响  

Research of Dingchuan Decoction on Airway Remodelling and Eosinophil of Asthmatic Rats

作　　者：于鸿[1] 计忠宇[1] 赵辉[1] 卢丽艳[1] 

机构地区：[1]河北医科大学沧州中西医结合临床医学院,河北沧州061001

出　　处：《中国中医急症》2011年第9期1437-1438,共2页Journal of Emergency in Traditional Chinese Medicine

基　　金：河北省沧州市科技局科研课题(06ZD224)

摘　　要：目的观察定喘汤抑制支气管哮喘大鼠模型气道重塑和嗜酸粒细胞浸润的作用。方法 50只健康大鼠按随机数字表法分成正常对照组、哮喘模型组、定喘汤低、中、高剂量组,以卵白蛋白(OVA)致敏激发制备大鼠哮喘模型,观察各组大鼠肺组织病理学改变,测定外周血中总IgE水平和肺泡灌洗液中嗜酸粒细胞计数。结果哮喘模型组肺组织病理学改变明显;对外周血中总IgE水平,肺泡灌洗液中嗜酸粒细胞计数的影响,定喘汤各剂量组与哮喘模型组比较有显著差异,定喘汤低、中、高剂量组比较无显著差异。结论定喘汤治疗支气管哮喘的机制部分可能是通过抑制气道重塑和减少嗜酸粒细胞浸润而实现的。Objective：To observe the effect of Dingchuan Decoction on the airway remodelling and inhibition of inflammatory cells in rats with asthmatic.Methods：50 rats were randomly divided into 5 groups：the normal group,the model group,the Dingchuan Decoction low-dose group,the Dingchuan Decociton medium-dose group and the Dingchuan Decociton high-dose group.The chronic asthmatic model was established by repeated inhalation of ovalbumin.Rats were compared the morphological change of bronchial and lung tissues,the IgE of peripheral blood and the number of EOS in bronchoalveolar lavage fluid.Results：Comparing with the normal group and these Dingchuan Decoction groups,the bronchial and lung tissue morphology of the model group were significantly changed.Also,IgE of peripheral blood and the number of EOS in bronchoalveolar lavage fluid of the model group were significantly increased.There were some obvious differences among the the normal group and the Dingchuan Decoction groups in the IgE and EOS.However,there were no remarkable differences among these Dingchuan Decoction groups in the IgE and the EOS.Conclusion：Dingchuan Decoction can treat asthma possibly by inhibition of the airway remodelling and decrease IgE and EOS

关 键 词：定喘汤 哮喘 气道重塑 嗜酸粒细胞 

分 类 号：R285.5[医药卫生—中药学]