泼尼松和胱抑素C及肌酐联合检测在肾病综合征中的临床价值  

Clinical value of combination detection of prednisone,cystatin C and creatinine in nephrottic syndrome

作　　者：张旭光[1] 赵姝姝[1] 李加村[1] 王海霞[1] 王云海[1] 

机构地区：[1]潍坊医学院附属医院检验科,山东潍坊261031

出　　处：《检验医学与临床》2011年第18期2223-2224,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨泼尼松、胱抑素C与肌酐浓度监测在肾病综合征中的临床价值。方法对54例肾病综合征患者分别用高效液相色谱法、乳胶增强散射免疫比浊法及酶比色法对泼尼松、胱抑素C及肌酐水平进行检测。结果治疗前除微小病变肾病综合征外,健康对照组和肾病综合征组胱抑素C与肌酐浓度差异均有统计学意义(P<0.01);治疗后泼尼松保持稳态血药浓度时,胱抑素C浓度降低(P<0.05)且相对稳定,而肌酐浓度变异较胱抑素C大,但与治疗前相比差异无统计学意义(P>0.05)。结论胱抑素C是肾病综合征疗效观察更敏感的指标,泼尼松与胱抑素C联合检测更具有临床价值。Objective To discuss the clinical value of prednisone,cystatin C and creatinine monitoring in nephrotic syndrome. Methods The serum levels of prednisone, cystatin C and creatinine in 54 patients with nephrotic syndrome were detected by HPLC,latex-enhanced immunoturbidimetry and enzymic colorimetric methods respectively. Results The concentrations of cystatin C and creatinine between normal control and nephrotic syndrome group had statistical difference besides minimal change nephrotic syndrome in pretherapy（P〈0. 01）;the concentration of cystatin C were lower（P〈0. 05） and stable but creatinine was astable （P2〉0.05） when prednisone remaining plateau concentration in post-therapy. Conclusion Cystatin C is a more sensitive marker of curative therapy observation to nephrotie syndrome,the combination detection of prednisone and cystatin C has more clinical value.

关 键 词：泼尼松 胱抑素C 肌酸酐 肾病综合征 

分 类 号：R692[医药卫生—泌尿科学]