1H-吡唑[3,4-b]吡啶的合成研究  

Synthesis of 1H-pyrazolo[3,4-b] pyridine

作　　者：黄斌[1] 张征林[2] 

机构地区：[1]东南大学成贤学院,江苏南京210088 [2]东南大学化学化工学院,江苏南京210088

出　　处：《化学试剂》2011年第9期841-842,864,共3页Chemical Reagents

摘　　要：以2-氯烟酸为起始原料,经过还原、氧化、肟化及环合反应合成了标题化合物,4步反应总收率67.21%。产品经1HNMR和质谱表征。该方法具有操作简单、成本低、环境友好等优点,适合工业化生产。1H-Pyrazolo[3,4-b] pyridine was synthesized by using 2-chloronicotinic acid as the starting material via reduction,oxidation,oximation and cyclization.The total yield of four steps was 67.21%.The structure of the product was confirmed by 1HNMR,and MS.This method has many advantages,such as easy operation,low cost and environment-friendly,which can be feasible to large scale preparation.

关 键 词：2-氯烟酸 还原 氧化 肟化 环合 1H-吡唑[3 4-b]吡啶 

分 类 号：O626.21[理学—有机化学]