C肽与颈动脉内膜中层厚度的相关性研究  

The correlation between serum C-peptide and intima-media thickness of carotid artery

作　　者：刘谦[1] 秦明照[1] 王云[1] 陈一文[1] 崔瑶[1] 葛维莹[1] 

机构地区：[1]首都医科大学附属北京同仁医院干部医疗科,北京100730

出　　处：《中国糖尿病杂志》2011年第9期688-690,共3页Chinese Journal of Diabetes

摘　　要：目的通过测定不同C肽（C-P）水平患者的颈动脉内膜中层厚度（IMT），研究C-P与动脉粥样硬化的关系。方法以正常糖代谢、糖耐量减低及2型糖尿病病程小于5年的112例患者为研究对象，根据C-P三分位间距分为A、B、C组，应用彩色多普勒超声仪测定颈动脉IMT，并测量腰围、体质指数、血糖、血脂、尿酸等，各组间进行单因素方差分析，差异有统计学意义的指标与C-P水平进行Pearson相关分析，同时记录用药情况进行行×列x^2检验。结果各组间IMT的差异有统计学意义（P〈0．05），B组和C组高于A组（P〈0．05）；同时腰围、体质指数、尿酸、甘油三酯存在差异且与C-P呈正相关；三组间高密度脂蛋白胆固醇差异有统计学意义（P〈0．05），C组明显低于A组（P〈0．05），B组与A组无明显统计学差异（P〉0．05），且HDL-C与C-P呈负相关。结论随着C-P水平的升高IMT增加，在胰岛素抵抗及病程小于5年的2型糖尿病中升高的C-P可能反映动脉粥样硬化的发生。Objective To study the correlation between serum C-peptide and the intima-media thickness（IMT） of carotid artery. Methods A total of 112 patients with normal glucose metabolism, impaired glucose tolerance and type 2 diabetes（〈5 years in duration）were divided into group A, B, C according to 33 and 66 percentile values of C- peptide. The IMT were measured by color Doppler ultrasound instrument. The basal values of waist circumferences （WC）, body mass index（BMI）, lipid, glucose, and uric acid （UA） were recorded. The comparison of differences between the three groups was assessed by ANOVA and Chi-square test. Pearson correlation was employed to assess the relationship between C-peptide and biomedical parameters. Results There were differences in the IMT among 3 groups （P〈0.05）. The IMT in group B and C was higher than in group A（P〈0.05）. Meanwhile, there were differences in WC, BMI, UA, triglycerides （TG）, high density lipoprotein-cholesterol（HDL-C） among 3 groups. C-peptide level was positively associated with WC, BMI, UA, TG, but negatively with HDL-C. Conclusions IMT of carotid artery increases along with the increasing of C-peptide level. The C-peptide may be associated with atherosclerosis in type 2 diabetic patients with insulin resistance and duration less than 5 years.

关 键 词：C肽 动脉粥样硬化 胰岛素抵抗 糖尿病 2型 内膜中层厚度 

分 类 号：R587.1[医药卫生—内分泌]