大承气汤血中移行成分的代谢分析  

The Metabolism Analysis of the Specific Transitional Component in the Rat Blood After Oral Administration of Da Cheng Qi Tang

作　　者：耿耘[1] 肖秋元[1] 李海霖[2] 马超英[1] 

机构地区：[1]西南交通大学生命科学与工程学院,四川成都610031 [2]青海省中医院制剂中心,青海西宁810000

出　　处：《中华中医药学刊》2011年第9期1961-1962,I0001,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30873365);中央高校基本科研业务费专项研究资助项目(SWJTU09ZT29)

摘　　要：目的:通过分析口服给药后大鼠血清中成分,以确定中药及复方的体内直接作用物质。方法:待大鼠给药大承气汤吸收入血后取血,利用HPLC-DAD方法分析检测血中移行成分。结论:大鼠给药大承气汤复方后,不同部位血清中入血成分含量不同,因此可以推测,大鼠不同取血方法获得的血液中血清移行成分含量不同,且在色谱条件68.79min处,存在一特定的某血清移行成分,物质在401nm处有很大吸收。Objective ： To determine the direct effective compounds in vivo of DT by analyzing the rats＇ serum after oral administration of DT. Methods：Rats＇blood is gathered after DT administration, and then transitional components in bloodare detected by HPLC - DAD. Conclusion ： The contents of ingredients into the blood serum in different parts are different after DT administration in rats. It can be speculated that the contents of transitional components of serum are different as a result of different blood obtained ways, and on the chromatographic condition of 68.79min, there was a specific transi- tional component of serum with a great absorption at 401nm.

关 键 词：大承气汤 血中移行成分 HPLC 

分 类 号：R285.5[医药卫生—中药学]