关节置换术后感染与降钙素原的关系探讨  

Discussion of the relationship between postoperative infection after joint repalcement and procalcitonin

作　　者：窦超[1] 赵林[1] 武星[1] 

机构地区：[1]青岛大学医学院附属医院手术室,山东青岛266003

出　　处：《中华医院感染学杂志》2011年第17期3578-3580,共3页Chinese Journal of Nosocomiology

基　　金：山东省科技发展计划(2010GWZ20225)

摘　　要：目的探讨人血清降钙素原(PCT),在人工关节置换术后感染中的诊断意义。方法收集2008年9月-2010年10月,青岛市关节置换患者40例,其中20例为关节置换术后并发感染者分为感染组;20例非感染患者分为对照组,分别于感染组翻修术前24h、对照组关节置换术后24h采取静脉血,离心获取血清,用免疫比浊法检测患者血清当PCT与C-反应蛋白(CRP)的浓度,对比两指标诊断关节置换术后感染的敏感性及特异性。结果 PCT对关节置换术后感染诊断的敏感性为95%,特异性为100%,特异性明显优于CRP,差异有统计学意义(P<0.01)。结论 PCT可以作为关节置换术后感染诊断的理想指标,结合CRP更有助于关节置换术后感染的诊断。OBJECTIVE To explore the significance of human serum procalcitonin（PCT） in the diagnosis of postoperative infection after joint replacement.METHODS A total of 40 cases of joint repacement from a first class hospital in Qiangdao city between Sep 2008 and Oct 2010 were collected.20 cases had the complications of prosthesis infection and were notifed infection group.20 cases didn＇t have the Complications of prosthesis infection and were notifed control group.The Venous blood of the infection group were extracted at the time of 24 hours before revision surgery;the venous blood of the control group were extracted at the time of 24 hours after joint replacement surgery.The level of human serum PCT and CRP（C-reactive protein） measured by immuno-turbidity method were compared with the sensibility and specificity of PCT and CRP in the diagnosis of infection after the joint replacement sugery.RESULTS The sensibility of PCT in the diagnosis of prosthesis infection was 95%,the specificity was 100%,and the specificity was obviously better than CRP（P〈0.01）.CONCLUSION PCT can be used as an ideal diagnostic index of prosthesis infection,PCT combined with CRP were better useful to the diagnosis of prosthesis infection.

关 键 词：关节置换 感染 降钙素原 C-反应蛋白 诊断 

分 类 号：R687.3[医药卫生—骨科学]