重症肺炎患者血清高迁移率族蛋白B1检测的临床应用  

Clinical application of serum high mobility group box 1 in patients with severe pneumonia

作　　者：刘洁[1] 胡志刚[2] 陈国千[2] 

机构地区：[1]无锡市人民医院呼吸科,江苏无锡214023 [2]无锡市人民医院检验科,江苏无锡214023

出　　处：《中华医院感染学杂志》2011年第17期3587-3589,共3页Chinese Journal of Nosocomiology

基　　金：江苏省自然科学基金(BK200602)

摘　　要：目的调查重症肺炎患者高迁移率族蛋白B1(HMGB1)、C-反应蛋白(CRP)、白细胞计数(WBC)水平的变化及其临床意义。方法检测27例健康对照者、35例普通肺炎患者和25例重症肺炎患者的血清HMGB1水平及C-反应蛋白、白细胞计数;分析血清HMGB1水平与C-反应蛋白、白细胞计数等与肺炎的关系。结果重症肺炎、普通肺炎患者血清HMGB1、CRP、WBC水平显著性高于健康对照组(P<0.01);重症肺炎患者血清HMGB1水平(16.8±11.2)ng/ml,显著性高于普通肺炎患者的(6.2±3.8)ng/ml;重症肺炎、普通肺炎患者血清CRP、WBC水平的比较差异均有统计学意义(均P<0.05),重症肺炎患者治疗后HMGB1水平(6.8±3.9)ng/ml,显著低于治疗前的(16.8±11.2)ng/ml(P<0.01);重症肺炎患者治疗后HMGB1水平显著高于健康对照组(P<0.01)。结论肺炎患者血清HMGB1水平明显升高,血清HMGB1水平测定可作为评价肺炎病变和炎症反应程度的有效指标。OBJECTIVE To investigate the change and the clinical significance of serum HMGB1 level of severe pneumonia.METHODS Serum HMGB1and CRP and WBC levels were determined in 27 healthy individuals and 35 patients of common pneumonia and 25 patients of severe pneumonia.The correlation between serum HMGB1 level and serum C-reactive protein level or white blood cell count in acute pancreatitis were analyzed.RESULTS The level of Serum HMGB1 and CRP and WBC were significantly higher in patients with severe pneumonia and the patients with common pneumonia than the healthy matched control（P〈0.01）.Serum HMGB1 level of the patients of severe pneumonia（16.8±11.2）ng/ml were significantly above the patients of common pneumonia（6.2±3.8）ng/ml（P〈0.01）.There have significant difference of CRP and WBC between the patients of severe pneumonia and the patients of common pneumonia（P〈0.05）.Serum HMGB1 level of the patients of severe pneumonia after post-treatment（6.8±3.9）ng/ml were significantly below the patients of pretherapy（16.8±11.2）ng/ml（P〈0.01）.Serum HMGB1 level of the patients of severe pneumonia after post-treatment were significantly above the healthy matched control（P〈0.01）.CONCLUSION Serum HMGB1 level is significantly elevated in the patients with pneumonia.The level measurement of the serum HMGB1 is a valid index sign which evaluates pneumonia pathological changes and respond degree of inflammatory reaction.

关 键 词：肺炎 高迁移率族蛋白B1 炎症介质 血清 

分 类 号：R181.32[医药卫生—流行病学]