肺癌并发肺部感染患者外周血T淋巴细胞亚群水平研究  

Study on peripheral blood T lymphocyte subsets of patients with lung cancer and lung infection

作　　者：冯湘平[1] 赵辉[1] 陆强[1] 唐琼[1] 

机构地区：[1]天津市人民医院呼吸科,天津300191

出　　处：《中华医院感染学杂志》2011年第17期3600-3602,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨肺癌并发肺部感染患者外周血T淋巴细胞亚群水平变化规律。方法选取2008年1月-2010年12月,在医院进行治疗的93例肺癌患者为研究对象,将其根据是否伴有肺部感染分为不伴有感染组(对照组)47例,伴有感染组(观察组)46例,将2组患者的CD3+、CD4+、CD8+、CD4+/CD8+及NK水平进行统计及比较。结果观察组的CD3+(60.82±5.96)%、CD4+(30.58±3.78)%、CD4+/CD8+(1.02±0.15)%、NK(19.20±5.97)%,对照组的CD3+(65.38±5.89)%、CD4+(37.85±3.69)%、CD4+/CD8+(1.43±0.18)%、NK(22.76±6.12)%,观察组均低于对照组,差异有统计学意义(P<0.05);观察组CD8+(29.75±2.66)%,对照组(25.76±2.58)%,观察组高于对照组差异有统计学意义(P<0.05),且不同分期患者中的CD3+、CD4+、CD8+、CD4+/CD8+及NK水平均呈现这种规律。结论肺癌并发肺部感染患者免疫力更差,治疗过程中应引起重视。OBJECTIVE To study the variation of peripheral blood T lymphocyte subsets of patients with lung cancer and lung infection.METHODS A total of 93 patients with lung cancer in our hospital from Jan 2008 to Dec 2010 were selected as research object,and they were divided into control group（without infection group）47 cases and observation group（with infection group）46 cases,then the CD3＋,CD4＋,CD8＋,CD4＋/CD8＋ and NK of two groups were analyzed and compared.RESULTS The CD3＋,CD4＋,CD4＋/CD8＋ and NK of observation group [（60.82±5.96）%,（30.58±3.78）%,1.02±0.15,（19.20±5.97）%] were lower than those of control group [（65.38±5.89）%,（37.85±3.69）%,1.43±0.18,（22.76±6.12）%].CD8＋ was higher than that of control group [（25.76±2.58）% vs（29.75±2.66）%],（P〈0.05）.And CD3＋,CD4＋,CD8＋,CD4＋/CD8＋ and NK of different stages all showed this regulation.CONCLUSION The patients with lung cancer and lung infection are more immunocompromised,and it should pay attention to the course of treatment.

关 键 词：肺癌 肺部感染 外周血T淋巴细胞亚群 变化规律 

分 类 号：R181.32[医药卫生—流行病学]