宫颈阴道分泌物FFN与血清IL-6预测早产并绒毛膜羊膜炎的价值  

Value of combined detection of fetal fibronectin of cervicovaginal secretion,interleukin-6 in predicting preterm delivery and chorioamnionitis

作　　者：王晓秋[1] 谢芳 戴丛伟 金红 陈秀清 

机构地区：[1]瑞安市人民医院妇产科分院妇产科,浙江瑞安325200

出　　处：《中华医院感染学杂志》2011年第17期3638-3640,共3页Chinese Journal of Nosocomiology

基　　金：瑞安市科技局课题(20102065);温州市医药卫生科研项目(2011B060)

摘　　要：目的探讨宫颈阴道分泌物胎儿纤维连接蛋白(FFN)与血清白细胞介素6(IL-6)预测早产并绒毛膜羊膜炎的价值。方法采用ELISA法测定105例早产孕妇(早产组)和105例同期同孕周的正常孕妇(对照组)的宫颈阴道分泌物FFN和血清IL-6水平。结果早产组孕妇FFN和IL-6水平明显高于对照组,差异有统计学意义(P<0.01);早产组绒毛膜羊膜炎60例,对照组6例,差异有统计学意义(P<0.01);早产并绒毛膜羊膜炎孕妇的FFN和IL-6水平,明显高于早产无绒毛膜羊膜炎孕妇,差异有统计学意义(P<0.01);FFN预测早产并绒毛膜羊膜炎的敏感度和阴性预测值高于IL-6,特异度和阳性预测值则较低。结论宫颈阴道分泌物FFN和血清IL-6,均是预测早产并绒毛膜羊膜炎的敏感指标,联合检测将大大提高准确性和可靠性。OBJECTIVE To investigate the value of combined detection of fetal fibronectin of cervicovaginal secretion,interleukin-6 in predicting preterm delivery and chorioamnionitis.METHODS Cervicovaginal secretion samples were obtained from 105 patients with preterm labor（preterm group）and 105 pregnant women（control group） between the same gestational weeks,and the levels of FFN,IL-6 were measured by ELISA.RESULTS The FFN and IL-6 levels in preterm group were significantly higher than those in control group,the difference was statistically significant（t=10.52,6.73,P〈0.01）.Chorioamnionitis in preterm group were 60 patients,while in the control group were 6 cases,the difference was statistically significant（χ2=64.43,P〈0.01）.The sensitivity in predicting chorioamnionitis and the negative predictive value were higher with FFN than those with IL-6,but the specificity and the positive value predicted by IL-6 were lower than those by FFN.CONCLUSION Fetal fibronectin of cervicovaginal secretion and interleukin-6 are sensitive indicators of chorioamnionitis,and the combined detections of FFN,IL-6 will greatly enhance the accuracy and reliability.

关 键 词：胎儿纤维连接蛋白 白细胞介素6 早产 绒毛膜羊膜炎 

分 类 号：R181.32[医药卫生—流行病学]