209株真菌感染分布及耐药分析  

Analysis of distribution and drug-resistance of 209 funged strains

作　　者：胥振国[1] 蔡玉华[1] 袁星[1] 张蓉[2] 胡开明[2] 

机构地区：[1]巢湖职业技术学院,安徽巢湖238000 [2]安徽省巢湖市第一人民医院检验科,238000

出　　处：《蚌埠医学院学报》2011年第9期1004-1006,共3页Journal of Bengbu Medical College

基　　金：安徽省高校省级自然科学研究资助项目(KJ2011B106)

摘　　要：目的:了解临床真菌的感染分布及耐药现状,为临床合理使用抗真菌药物提供依据。方法:对巢湖市第一人民医院2010年分离的209株真菌进行微生物学鉴定和药敏试验。结果:白色念株菌检出最高为148株(70.82%);其次为热带念珠菌30株(14.35%);痰液标本真菌检出率最高(67.46%),患者大部分为60岁以上老年人。真菌对5-氟胞嘧啶、两性霉素B敏感率较高,在98%以上,对伊曲康唑敏感性稍低(79.32%)。结论:真菌感染以白色念珠菌和热带念珠菌较为常见,而且耐药菌株的检出率呈上升趋势,临床上应慎用抗菌药物,减少耐药菌株的产生。Objective：To investigate the distribution and resistance of fungus in order to provide basis for antifungal clinical treatment.Methods：Microbiological assay and drug sensitive test were performed on 209 strains of clinical lyisolated separated fungus in the first people hospital of Chaohu city from Jan.to Dec.in 2010.Results：Two hundred and nine fungal strains were detected from various clinical submitted specimens in our hospital and Candida albicans had the highest detection rate of 70.82%（148 strains）,followed by C.tropicalis with 14.35%（30 strains）.The largest isolation rate of 67.46% was in sputum specimens.In the age distribution patients above 60 years old had the largest portion.In vitro antifungal susceptibility test revealed that fungi had higher sensitivity（98%）to 5 fluorocytosine and amphotericin B,slighter sensitivity to azole drugs（79.32%）.Conclusions：In fungal infections,candida albicans,and candida tropicalis,are more common,and the detection rate of drug resistant strains shows upward trend,suggesting that the use of antibiotics in clinic should be prudent to reduce the drug resistant strains.

关 键 词：真菌 抗真菌药 药敏试验 

分 类 号：R446[医药卫生—诊断学]