DNA定量细胞学与液基细胞学联合检测宫颈癌的研究进展  

Study Progress of the Combination of DNA Quantitative Cytology and TCT in Cervix Carcinoma Screening

作　　者：武卫华[1] 曹红英[1] 黄庆玉[2] 

机构地区：[1]山东省单县中心医院病理科,山东菏泽274300 [2]泰山医学院,山东泰安271000

出　　处：《医学综述》2011年第17期2689-2691,共3页Medical Recapitulate

摘　　要：液基薄层细胞学技术在很大程度上克服了传统细胞学技术的不足,明显提高了标本的满意度及宫颈异常细胞的检出率。DNA作为遗传物质,其结构和功能的异常,是细胞恶变的分子基础,通过细胞核内DNA水平的测定,能了解正常细胞周期变化及发现恶性增殖的肿瘤细胞。液基细胞学技术结合应用DNA倍体定量分析对宫颈癌和癌前病变有更高的预测价值,为宫颈癌早期诊断及降低患病率提供理论依据。With the application of thinprep cytology test （TCT）, the sensitivity of screening for cervical neoplastic lesions has developed greatly. DNA as the genetic material, its abnormal structure and function is the molecular basis of malignant transformation of cells. By testing the nuclear DNA content, the normal cell cycle can be understood and the proliferation of malignant tumor cells can be found,The combination with the automated DNA imaging cytometry can predict cervical carcinoma and precancerous lesion has higher predictive value ,providing theoretical basis for early diagnosis of cervical cancer and lowering the incidence.

关 键 词：液基薄层细胞学技术 DNA定量分析 全自动DNA倍体分析系统 宫颈癌 

分 类 号：R711.74[医药卫生—妇产科学]