不同受精方式对获卵数较少患者妊娠结局的影响  

Influence of different fertilization methods on the clinical outcomes of low oocytes retrieved

作　　者：吴昕[1] 罗艳[1] 刘春莲[1] 胡蓉[1] 景万红[1] 

机构地区：[1]宁夏医科大学附属医院,宁夏银川750004

出　　处：《宁夏医学杂志》2011年第9期826-828,共3页Ningxia Medical Journal

基　　金：宁夏生殖与遗传重点实验室开放课题(SY200804)

摘　　要：目的比较获卵数少的患者采用不同受精方式对其妊娠结局的影响。方法回顾性分析127个周期获卵数少于6个的患者,采用体外受精(IVF)或卵胞浆内单精子显微注射术(ICSI),比较两组受精率、多精受精率、取消周期率以及妊娠率的差异。结果两组患者年龄、不孕年限、不孕原因差异无统计学意义(P>0.05);两组患者获成熟卵率、可移植胚胎率、优质胚胎率、周期取消率、临床妊娠率差异无统计学意义(P>0.05)I,CSI组较IVF组受精率、冷冻周期率明显高(P<0.05);两组按精液情况分层,男方精液正常的患者ICSI组比IVF组受精率明显升高(P<0.05),但在多精受精率、可移植胚胎率、优质胚胎率、冷冻周期率、取消周期率和临床妊娠率、单个取卵周期累计妊娠率等差异均无统计学意义;男方临界精液质量组的患者ICSI组可移植胚胎、冷冻周期率、取卵周期累计妊娠率较IVF组显著增加(P<0.05),周期取消率明显降低(P<0.05),受精率、优质胚胎率和临床妊娠率均高于IVF组,但无统计学意义(P>0.05)。结论男方临界精液质量组获卵少患者采用ICSI可提高卵子的利用率及累计妊娠率,男方精液正常获卵少患者行ICSI无明显优势。Objective To compare the efficacy of intracytoplasmic sperm injection（ICSI） and in vitro fertilization（IVF） in patients with poor ovarian response.Methods 127 cycles of poor responders with less than six retrieved oocytes were retrospectively analyzed.Group IVF and group ICSI were compared in terms of fertilization rate,cleavage rate,ET（embryo transfer） cancellation rate and pregnancy rate.Results The patients in two groups with age and causes of infertility and period of infertility were no significant difference（P 0.05）.Fertilization rate and frozen embryos rate in group ICSI were much higher than that in group IVF.The patients in two groups stratified according to semen situation： Sperm normal patients were done IVF or ICSI,there were significant differences in fertility rate（P0.05）;In ICSI group of semen critical patients portable embryos and accumulative total pregnancy rate were higher than that in group IVF（P0.05）,and embryo transfer cancellation rate was lower（P0.05）.Though the fertility rate,the quality embryos rate and pregnancy rate were higher than IVF groups,it had no statistical significance（P0.05）.Conclusion ICSI can improve fertility rate in normal semen cycle,but it can＇t change the consequence of pregnancy.ICSI can improve the fertility rate and pregnancy rate to some degrees in critical semen quality groups of patients.

关 键 词：卵胞浆内单精子显微注射术 体外受精-胚胎移植 妊娠率 

分 类 号：R714.8[医药卫生—妇产科学]