盐酸非索非那定合成工艺的改进  

An Improved Synthesis of Fexofenadine

作　　者：袁军皇[1] 郑睿[1] 沈健芬[1] 成月[1] 

机构地区：[1]台州学院医药化工学院,浙江台州317000

出　　处：《精细化工中间体》2011年第1期37-38,共2页Fine Chemical Intermediates

基　　金：浙江省教育厅科研资助项目(Y200803040)

摘　　要：以苯、甲基丙烯醇乙酸酯和氯丁酰氯为原料,经傅-克烷基化和傅-克酰基化反应,然后进行水解、氧化、偶联、硼氢化钠还原、成盐制得盐酸非索非那定,总收率为42.0%。该法具有收率高、成本低、环境友好、路线短等优点。Fexofenadine hydrochloride was synthesized from benzene and methylallyl acetate via Frictel-Cratts alkylation, acylation, hydrolysis, oxidation, coupling and reduction. The overall yield was 42.0%. Comparing to the other methods, this synthetic route has advantages of high yield, low-cost and environmentally friendly.

关 键 词：抗组胺药 非索非那定 合成 

分 类 号：R976[医药卫生—药品]