应用ROC曲线评价血清β-hCG、黄体酮和子宫内膜厚度对异位妊娠的诊断价值  

The diagnostic significance of applying the ROC curve to evaluate the β-hCG,progesterone and endometrial thickness

作　　者：张振东[1] 孙丽君[1] 罗莹[1] 李欣[1] 孙冬梅[1] 

机构地区：[1]遵义医学院附属医院妇科,贵州遵义563003

出　　处：《重庆医学》2011年第26期2622-2624,共3页Chongqing medicine

摘　　要：目的探讨β-hCG、黄体酮、子宫内膜厚度及三项联合检测对异位妊娠的诊断价值。方法采用受试者工作特征曲线(ROC)对113例疑似异位妊娠患者的血清β-hCG、黄体酮、子宫内膜厚度及三项联合检测结果进行分析评价。结果异位妊娠组与正常宫内妊娠组比较,血清β-hCG、黄体酮、子宫内膜厚度均明显较低(P<0.01),与异常宫内妊娠组比较,仅子宫内膜厚度较低(P=0.018)。异常宫内妊娠组与正常宫内妊娠组比较,黄体酮、子宫内膜厚度均明显较高(P=0.005)。异位妊娠的血清β-hCG、黄体酮、子宫内膜厚度及三项联合检测在ROC曲线下面积分别为0.683、0.701、0.778及0.843。血清β-hCG、黄体酮、子宫内膜厚度对异位妊娠的临床诊断临界点分别为903 U/L、21.5 ng/mL、8.35 mm。结论血清β-hCG、黄体酮、子宫内膜厚度三项联合检测血清β-hCG可显著提高异位妊娠诊断的灵敏度,优于血清β-hCG、黄体酮和子宫内膜厚度的单项检测。Objective To study the diagnostic value of β-hCG, progesterone, endometrial thickness and combined delection of them in ectopic pregnancy. Methods The β-hCG, progesterone, endometrial thickness combined with the three indexes of 113 patients of the suspected ectopic pregnancy were detected and evaluated by ROC curve. Results The β-hCG, progesterone, endometrial thickness were significantly lower in that of the ectopic pregnancy than the group of the normal uterine pregnancy（ P〈0. 001 ）, and only the endometrial thickness is thinner than the group of the abnormal uterine pregnancynormal uterine pregnancy（P〈0. 018）; compared the group of the normal uterine pregnancy with the group of the abnormal uterine pregnancynormal uterine pregnancy, progesterone and endometrial thickness are significantly higher（P〈0. 005）. The areas under ROC curve of β-hCG, progesterone anti endometrial thickness and the joint detection of the three indexes were 0. 683,0. 701,0. 778 and 0. 843 respectively. The clinical di agnostic critical points of β-hCG,progesterone and endometrial thickness in ectopic pregnancy were 903 U/L,21.5 ng/mL and 8.35 mm,respectivelyConclusion The combination of the β-hCG,progesterone and endometrial thickness could significantly improve the sensitivity in diagnosis of the ectopic pregnancy,and is superior to the single detection of the three indexes respective.

关 键 词：ROC曲线 异位妊娠 绒毛膜促性腺激素血清β-hCG 黄体酮 子宫内膜厚度 诊断 

分 类 号：R714.22[医药卫生—妇产科学]