西番莲属植物的抗焦虑活性成分及其作用机制研究进展  

Progress on the Research of Anxiolytic Ingredients and the Mechanisms of Passiflora Linn

作　　者：赵瑞瑞[1,2] 邹江冰[1] 孔秋玲[1,2] 蒋琳兰[1,2] 

机构地区：[1]广州军区广州总医院药剂科,广东广州510010 [2]华南理工大学生物科学与工程学院,广东广州510006

出　　处：《食品与药品》2011年第9期354-357,共4页Food and Drug

基　　金：广州市基础研究计划项目(2005J1-C0352);广东省中医药局科研课题(2010253)

摘　　要：国外普遍将西番莲属植物用于治疗焦虑等疾病,近年国内外对其活性成分和作用机制进行了研究。认为γ-氨基丁酸(GABA)、亲脂性物质、苯并黄酮、白杨素、β-咔啉吲哚生物碱等是西番莲属植物中具有抗焦虑活性的成分,其作用机制涉及到GABA-苯二氮受体复合体的作用、芳香酶抑制作用、单胺氧化酶抑制作用等。Passiflora Linn has been widely used on the treatment of anxiety. Its active ingredients and the action mechanism has been studied by researchers home and abroad. These studies show that the antianxiety compounds of Passiflora Linn are：γ-aminobutyric acid（GABA）, lipophilic compounds, benzoflavone（BZF）, chrysin, β-Carboline and indole alkaloids. Its functional mechanism consists of the effect on GABA-benzodiazepines receptor compounds, the inhibition of aromatase and monoamine oxidase.

关 键 词：西番莲属 抗焦虑 活性成分 作用机制 

分 类 号：R971.3[医药卫生—药品]