重症监护病房铜绿假单胞菌引发肺部感染的临床分析  

Clinical analysis on pulmonary infection caused by Pseudomonas aeruginosa in ICU

作　　者：欧阳玲[1] 张玲[2] 王厚照[2] 姚一[1] 

机构地区：[1]解放军第一七四医院神经外科,福建厦门361003 [2]解放军第一七四医院检验科,福建厦门361003

出　　处：《临床和实验医学杂志》2011年第17期1324-1325,共2页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨重症监护病房(ICU)中铜绿假单胞菌(Pseudomonas areuginosa,PA)感染的临床表现、易感因素及耐药性。方法回顾性分析2010年1～12月ICU连续分离的89株PA感染的临床资料。结果患者均为医院感染,多伴有其他致病菌检出;抗菌药物体外敏感试验敏感率>50.0%的仅有阿米卡星、环丙沙星和头孢他啶;易感因素有:高龄35例(39.33%),多次静脉穿刺89例(100.0%),合并基础疾病69例(77.53%),应用广谱抗菌药物89例(100%),机械通气89例(100%),一次连续住院时间>14 d 89例(100.0%)。结论 PA肺部感染是医院获得性肺炎最常见的一种,对多种抗生素呈现很高的耐药性,要引起广泛的关注。Objective To study the clinical manifestations, susceptible factors and drug resistance of Pseudomonas aeruginosa infection in patients of ICU to provide the basis for clinical treatment. Methods The clinical data of 89 isolates of P. aeruginosa from ICU patients during January to December, 2010 were retrospectively analyzed. Results All patients were infected with hospital - acquired pneumonia, most of them were associated with the growth of other pathogens. Antibiotic sensitivity testing showed that they were resistant to most antibiotics. The predisposing factors included old age （43.82%） , underlying diseases （77. 539% ） , long hospitalization time （ 100% ） , overuse of broad - spectrum antibiotics （ 100% ） and mechanical ventilation （ 100% ）. Conclusion The pneumonia caused by P. aeruginosa is a kind of common hospital - acquired pneumonia, and we should pay more attention to its high drug resistance to most antibiotics.

关 键 词：重症监护病房 铜绿假单胞菌 肺部感染 耐药性 

分 类 号：R446.5[医药卫生—诊断学]