前列地尔联合丹红治疗糖尿病神经病变疗效分析与评价  

A Clinical Research of Diabetic Neuropathy Treatment Based on Alprostadil Combined with Danhong

作　　者：刘英[1] 王伟[1] 谢晓敏[2] 

机构地区：[1]宁夏医科大学,宁夏银川市750001 [2]宁夏医科大学第二附属医院

出　　处：《临床合理用药杂志》2011年第07X期29-30,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察前列地尔联合中药丹红治疗糖尿病神经病变(DN)的疗效。方法 60例糖尿病神经病患者随机分为治疗组(30例)和对照组(30例),对照组单用前列地尔治疗,治疗组应用前列地尔加丹红治疗。两组糖尿病患者,于治疗前后测定血糖、糖化血红蛋白(HbA1 c)、血常规、血生化、肝功能、肾功能及血液流变学指标,同时,并测定运动、感觉神经传导速度,膀胱残余尿量治疗过程中观察,疗程3周,治疗后评估疗效。结果治疗组总有效率明显高于对照组。两组血液流变学各项指标除血细胞比容外均有明显改善,而以治疗组更为明显,治疗组HbA1 c下降,明显低于对照组及治疗前。两组均可改善神经传导速度及膀胱残余尿量,而以治疗组更为明显。结论丹红可以加强前列地尔的改善血液循环作用,两药合用可提高治疗效果。Objective To investigate the curative effect of Alprostadil and Chinese traditional medicine Danhong which were both used for diabetic neuropathy.Methods 60 diabetic neuropathy patients were divided into two parts averagely as treatment group and antitheses group.The members in antitheses group were used Alprostadil only when the treatment group were used Alprostadil and Danhong.Before and after treatment,the two group members were measured of blood glucose,glycated hemoglobin（HbA1c）,blood biochemistry,liver function,kidney function and blood rheology.At the same time,motor and sensory nerve conduction velocity were mensurated.During the treatment,residual urine volume of the patients were observed.Period of treatment is 3 weeks.Results The total effective efficiency of treatment group is much higher than antitheses group.The conditions of two groups′ blood rheology were both improved except hematocrit when treatment group is better.And HbA1c in treatment group decline more quickly than antitheses group and before treatment.The nerve conduction velocity and residual urine volume were improved and treatment group is better.Conclusion The improvement of blood circulation with Alprostadil can be enhanced by Danhong.It can improve the treatment effect of diabetic neuropathy when the two kinds of medicines are both used.

关 键 词：糖尿病神经病变 中医药疗法 前列地尔 丹红 

分 类 号：R587.2[医药卫生—内分泌]