阿德呋啉对人工感染鸡球虫病的疗效试验  

Efficacy of Adprin on Artificial Coccidiosis in Chicken

作　　者：吴丽君[1] 曾明华[1] 江善祥[2] 阮祥春[1] 万荣峰[2] 

机构地区：[1]安徽农业大学动物科技学院,合肥230036 [2]南京农业大学,南京210095

出　　处：《中国兽药杂志》2011年第9期29-31,共3页Chinese Journal of Veterinary Drug

基　　金：安徽省高校自然科学研究重点项目(KJ2009A034Z)

摘　　要：阿德呋啉属核苷酸类化合物,通过干扰球虫嘌呤代谢而发挥抗球虫作用。为评价其抗球虫效果,将该药分别以306、0、90 mg/kg浓度添加于饲料中治疗人工感染鸡球虫病,同时以磺胺喹噁啉500 mg/kg浓度拌料给药作为对照。结果表明,阿德呋啉高剂量组(90 mg/kg)具有良好的抗球虫效果,其抗球虫指数为183.2;中、低剂量组(306、0 mg/kg)与磺胺喹噁啉则疗效很差,抗球虫指数均在120以下。故建议阿德呋啉治疗剂量为90 mg/kg。Adprin is a compound of nucleoside with anticoccidiosis activity by interfering with the purine metabolism pathway of coccidia. Adprin was used to feed at the dose of 30, 60, 90 mg/kg for evaluating the anticoccidial efficacy chicken of artificial coccidiosis. Sulfaquinoxalinum was used for control. The results revealed that the dose of 90 mg/kg adprin had high efficacy with the ACI 183.2. But the moderate and lower dose of adprin and sulfaquinoxalinum had low efficacy with the ACI below 120. So the dose of 90 mg/kg was recommended.

关 键 词：阿德呋啉 鸡球虫病 疗效 

分 类 号：R969.4[医药卫生—药理学]