颈动脉粥样斑块和hs-CRP与冠心病的相关性分析  

Correlation Analysis of Carotid Atherosclerotic Plaque,hs-CRP and Coronary Heart Disease

作　　者：陈小玲[1] 许勇[1] 李春梅[2] 

机构地区：[1]四川省德阳市第二人民医院心内科,四川德阳618000 [2]四川省德阳市第二人民医院彩超室,四川德阳618000

出　　处：《临床医学工程》2011年第9期1364-1366,共3页Clinical Medicine & Engineering

摘　　要：目的研究冠心病患者冠心病与颈动脉斑块及血清高敏C反应蛋白(hs-CRP)的相关性。方法收集冠状动脉造影(CAG)患者109例,根据CAG结果确诊冠心病84例,非冠心病25例。冠心病组结合临床症状、心电图、心肌酶CK、CK-MB、TNT等资料,分为稳定性心绞痛、不稳定性心绞痛、急性心肌梗死三亚组。采用高频超声探测各组双侧颈动脉IMT和所形成斑块稳定性;以及测定血清hs-CRP。结果①冠心病组颈动脉斑块总发生率显著高于非冠心病组(P<0.01);不稳定性心绞痛亚组与急性心肌梗死亚组比较颈动脉不稳定型斑块发生率无明显统计学差异(P>0.05);不稳定性心绞痛亚组、急性心肌梗死亚组颈动脉不稳定型斑块发生率均明显高于稳定性心绞痛亚组(P<0.05)。②冠心病组hs-CRP平均值高于非冠心病组平均值(P<0.05);不稳定性心绞痛亚组与急性心肌梗死亚组hs-CRP平均值比较无明显统计学差异(P>0.05);不稳定性心绞痛亚组、急性心肌梗死亚组hs-CRP平均值均明显高于稳定性心绞痛亚组(P<0.05)。结论颈动脉粥样硬化斑块的发生和血清hs-CRP的升高与冠心病有明显正相关性。通过高频超声颈动脉不稳定型斑块的检出,结合血清hs-CRP的升高,可初步预测冠心病患者冠状动脉硬化的不稳定。Objective To evaluate the relation of carotid atherosclerotic plaque,serum levels of high sensitivity C reactive protein（hs-CRP） and coronary heart disease（CHD） in patients with CHD.Methods 109 patients who underwent coronary angiography were divided into two groups：CHD group（84 cases） and normal control group（25 cases）.The CHD group was divided into three sub-groups（stable angina sub-group,unstable angina sub-group and acute myocardial infarction sub-group） by the clinical symptom,electrocardiogram,CK,CK-MB,TNT.Carotid IMT and plaque stabilization were assessed by high frequency ultrasonography and serum levels of hs-CRP were measured in each patient.Results ①The incidence of plaque in the CHD group was significantly higher than that in the normal control group（P 0.01）.The incidence of unstable plaque in the unstable angina sub-group and the acute myocardial infarction sub-group had no obviously statistics difference with each other（P 0.05）.The incidence of unstable plaque in each the unstable angina sub-group and the acute myocardial infarction sub-group was higher than that in the stable angina sub-group（P 0.05）.②hs-CRP in the CHD group was higher than that in the normal control group（P 0.05）.hs-CRP in the unstable angina sub-group and acute myocardial infarction sub-group had no obviously difference with each other（P 0.05）.hs-CRP in each the unstable angina sub-group and the acute myocardial infarction sub-group was higher than that in the stable angina sub-group（P 0.05）.Conclusion The presence of carotid atherosclerotic plaques and the high serum levels of hs-CRP are related with the coronary artery disease.Angiographic morphology of the coronary artery lesion in CHD patients can be predicted by combination of ultrasonographic carotid soft plaque indices and high serum levels of hs-CRP.

关 键 词：冠心病 颈动脉斑块 血清高敏C反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]