秦香止泻方对小鼠小肠推进功能及镇痛作用的机制研究  

Mechanism study of Qinxiang Zhixie decoction on promoting small intestine and analgesic effect in mice

作　　者：朱克[1] 彭芝配[1] 张金慧 李文龙[1] 肖瑞飞[1] 田志刚 江壮岚[1] 滕久祥[1] 

机构地区：[1]湖南中医药大学 [2]韶关医学院药学系药学教研室,广东韶关512026

出　　处：《湖南中医药大学学报》2011年第5期23-25,共3页Journal of Hunan University of Chinese Medicine

基　　金：长沙市科技局课题(K1009002-31)

摘　　要：目的探讨秦香止泻方对正常小鼠小肠推进功能及冰醋酸致痛的镇痛作用。方法 (1)将40只SPF级昆明小鼠随机分为空白对照组、秦香止泻方低、中、高剂量组,分别给药后灌服碳末,处死动物观察小肠碳末推进率:(2)将50只SPF级昆明小鼠分组给药方法同(1),给药后腹腔注射2 mL冰醋酸,观察第1次扭体时间和30 min内各组小鼠扭体次数。结果 (1)秦香止泻方低、中、高剂量组与空白对照组组比较,小肠推进率基本相同,差异无统计学意义(P>0.05);(2)秦香止泻方低、中、高剂量组、肠康片组与空白对照组比较,疼痛潜伏时间均较空白对照组延长,差异具有统计学意义(P<0.05);扭体次数相比差异具有统计学意义(P<0.01);秦香止泻方中、高剂量组与肠康片组比较,疼痛潜伏时间延长,扭体次数亦减少,差异具有统计学意义(P<0.05)。结论秦香止泻方对正常小鼠小肠推进功能无明显抑制及推进作用;秦香止泻方低、中、高剂量组与肠康片组比较,扭体次数明显减少,提示秦香止泻方具有较好的镇痛作用。Objective To investigate the effect of Qinxiang Zhixie small intestine and analgesic effect in mice. Methods （1） 40 SPF mice into control groups, and low, medium and high dose ing medicine and then carbon powder respectively, the of small intestine. （2） 50 SPF mice were grouped 2 mL glacial acetic acid into abdominal cavity, the within 30 min. Results （1） compared with the control and high dose groups tablet group, the pain were nearly same （P〉0.05）. （2） latency time in all low, medium decoction on promoting were randomly divided of QinXiang Zhixie groups, after feedmice were killed to observe its propelling and feed like （1）, and then injecting first writhing time and times of writhing group, the propelling rates in low, medium Compared with control group and intestine and high dose groups was longer （P〈0.05）, the differences of the writhing times were significant （P〈0.01）; compared with the intestine tablet group, the pain latency prolonged and the writhing reduced in medium and high dose group （P〈0.05）. Conclusion QinXiang Zhixie decoction is not suppressed and is effective to remove pain.

关 键 词：秦香止泻方 小肠碳末推进 抗炎镇痛 小鼠 秦皮 木香 

分 类 号：R285.5[医药卫生—中药学]