肝苏颗粒与拉米夫定片中西药结合治疗慢性乙型肝炎疗效研究  

the Efficacy Study of Gansu Particles and Lamivudine Combination Treatment of Chronic Hepatitis B

作　　者：孙连先[1] 徐云[1] 

机构地区：[1]连云港市第二人民医院,江苏连云港222023

出　　处：《中国医药指南》2011年第27期21-22,共2页Guide of China Medicine

摘　　要：目的观察肝苏颗粒与拉米夫定片治疗慢性乙型肝炎(CHB)患者的疗效,并比较其差异。方法将60例CHB患者分拉米夫定片组,拉米夫定片与肝苏颗粒联合治疗组。观察和记录患者的症状、体征的变化及药物的不良反应,定期检测肝功能、HBV血清免疫标志物、HBV-DNA定量等项日,随访12个月。结果拉米夫定组,肝苏颗粒+拉米夫定组总有效半分别为63.3%和83.3%,两组在乙型肝炎复发方面有显著差异(P<0.01);拉米夫定+肝苏颗粒显效率为60%,拉米夫定片显效率为50%,两组有显著差异(P<0.05)。结论拉米夫定,肝苏颗粒+拉米夫定片治疗慢性乙型肝炎患者均有明显疗效,后者在AST复常方面效果更佳。Objective To observe the gansu particles and lamivudine treatment of chronic hepatitis b patients with（CHB） the curative effect,and compares their differences.Methods 60 patients with CHB patients points lamivudine piece of group,lamivudine piece with gansu particles joint treatment group.Watch and record the patient＇s symptoms,signs of change and drug adverse reactions,periodically liver function,HBV immune markers,serum HBV-DNA ration and so on a day,follow-up of 12 months.Results Lamivudine group,gansu particles＋lamivudine group total effective half 63.3% and 83.3%,respectively,in two groups of second liver recurrence a significant difference（P〈0.01）;lamivudine＋gansu particles significant efficiency is 60%,lamivudine piece of significant efficiency is 50%,two groups have significant difference（P〈0.05）.Conclusion Lamivudine and gansu particles＋lamivudine treatment of chronic hepatitis b patient all has the obvious curative effect,the latter in AST after often aspects the effect is much better.

关 键 词：肝苏颗粒 拉米夫定片 联合用药 慢性乙型肝炎 疗效观察 

分 类 号：R512.62[医药卫生—内科学]