血浆同型半胱氨酸、脑钠肽与冠状动脉病变程度的相关性研究  

Analysis of relationship between plasma homocysteine （Hcy） and B - type Natriuretlc Peptide Levels and the Severity of Coronary Disease

作　　者：邓阳春[1] 

机构地区：[1]湖南省永州职业技术学院附属医院,425100

出　　处：《健康必读（下）》2011年第9期34-34,28,共2页

摘　　要：目的：探讨血浆同型半胱氨酸（HCY）、脑钛钠（BNP）与冠状动脉（冠脉）病变程度的相关性。方法：回顾性分析本院收治的90例经冠状动脉造影确诊为冠心病患者的临床资料，根据冠状动脉造影结果分为以下3组：稳定型心绞痛组（SAP组）、不稳定型心绞痛组（UAP组）、非sT段抬高急性冠状动脉综合征组（NSTE—ACS组），每组各30侧；入院检测血清BNP水平和血浆Hcy含量、行冠脉造影。结果：SAP组与NSTE—ACS组冠脉病变支数构成比、左主干病变情况、Gensini评分无显著性差异（P〉0．05）；UAP组与SAP组、UAP纽与NsTE—ACS组的病变支数构成比、左主干病变情况、Gensini评分有显著性差异（P〈0．05）；二支摘变与三支病变的血浆Hcy水平均明显高于单支痛变（P〈0．05）；UAP组、NSTE—ACS组的血清BNP水平均高于UAP（P〈0．05）：结论：脑钠肽可作为反映冠心痛患者心肌爱损程度的指标．血浆Hcv水平与冠脉病变支数密切相关。Objective To analyze the relationship between plasma homocysteine （Hcy） and B - type Natriuretic Peptide Levels and the Severity of Coronary Disease. Method 90 patients who underwent coronary angiography and defined as having coronary heart diseases （ CHD ） were divided into 3 groups ： stable angina pectoris （ SAP ） group, unstable angina pectoris （USP） group and non - ST elevation acute coronary syndrome （ NSTE - ACS） group, The levels of Hey and the levels of BNP were measured at hospital admission. Results There were no significant differences in the number of impaired coronary arteries and left main coronary stenosis and Gensini between SAP group anti NSTE - ACS group （ P 〉 0.05 ）. The Hcy level in the group of triple - vessel and double - vessel are much higher than that in the group of single - vessel （ P 〈 0.05 ）. The BNP level in the UAP group and NSTE - ACS group are much higher than that in the UAP group. Conclusion Plasma levels of BNP is a important clinical parameters. Io reflect the severity of myocardial necrosis. The plasma Hcy level has relation with the number of coronary artery with stenosis.

关 键 词：冠心病 血浆B型脑钠肽 血浆同型半胱氨酸(Hcy)冠状动脉病变程度 

分 类 号：R541[医药卫生—心血管疾病]