糖基修饰大环化合物的研究进展  

Recent Progresses in Sugar-functionalized Macrocyclic Compounds

作　　者：杨芬[1,2] 张新建[1] 陈琦[1] 颜朝国[2] 韩宝航[1] 

机构地区：[1]国家纳米科学中心,北京100190 [2]扬州大学化学化工学院,扬州225002

出　　处：《高等学校化学学报》2011年第9期2010-2021,共12页Chemical Journal of Chinese Universities

基　　金：国家重大科学研究计划项目(批准号:2011CB932500);国家自然科学基金(批准号:20972035;21002017)资助

摘　　要：糖类分子作为生命过程中多种特殊受体的底物,在生物信息传递中发挥着重要的作用.近年来,已通过各种方法高效率地制备了一些新型的糖基修饰的杯芳烃、环糊精和冠醚等大环分子,它们在生物凝集素特异性识别、选择性离子识别及手性催化等方面的应用引起了研究者的广泛兴趣.本文从糖基修饰大环分子的合成、功能化及其相关应用方面综述了目前糖基功能化大环分子的研究进展.Carbohydrates,as a special substrate of specific receptors in many biological processes,play an important role in information communication.In recent years,more and more novel sugar-functionalized macrocyclic compounds such as calixarenes,cyclodextrins and crown ethers have been efficiently prepared and show the potential applications in lectin-pecific biological binding,selective ion recognition,and chiral catalysis.Introducing sugars into the macrocyclic system can not only produce various novel multivalent glycoconjugates,but also provide new binding sites for the macrocyclic compounds,which attracts more and more attention.In this review,recent progresses in the synthesis and applications of sugar-functionalized macrocyclic molecules have been summarized.

关 键 词：糖基 主-客体识别 大环化合物 超分子 

分 类 号：O629[理学—有机化学]