N-(4-羟基-苯基)-甘草次酸酰胺的合成  

Synthesis of N-(4-Hydroxylphenyl) Glycyrrhetinic Acid Amide

作　　者：雍建平[1] 赵巍[2] 

机构地区：[1]宁夏医科大学公共卫生学院,银川市胜利街1160号750004 [2]宁夏医科大学医学分子生物学实验室,银川市胜利街1160号750004

出　　处：《光谱实验室》2011年第5期2241-2244,共4页Chinese Journal of Spectroscopy Laboratory

基　　金：宁夏自然科学基金(NZ10108);宁夏医科大学面上基金(XM201010);宁夏医科大学博士学位建设学科开放课题(KF-2010-12)

摘　　要：以18β-甘草次酸和4-氨基苯酚为原料,在N,N′-二环己基碳二酰亚胺(DCC),1-羟基苯并三唑(HOBt)/4-N,N-甲基吡啶(DMAP),N-甲基吗啉(NMM)作用下合成了N-(4-羟基-苯基)-甘草次酸酰胺,通过DCC、DCC/HOBt催化有机酸形成酯、酰胺反应的历程解释了在DCC/HOBt催化体系中目标化合物产率高的原因,同时通过4-氨基苯酚在碱性环境中结构的变化及苯环上取代基的特性解释了标题化合物为主产物的原因。所合成的化合物通过IR,1H NMR,MS等方法进行了表征。N-（4-hydroxylphenyl）glycyrrhetinic acid amide was synthesized using 18β-glycyrrhetinic acid and 4-aminophenol in the presence of DCC,HOBt/DMAP,NMM.The reason with the higher yield catalyzed by DCC/HOBt,DCC was elucidated from the catalyzing reaction mechanism of the DCC and DCC/HOBt,and the reason of title compoud being the major product was explained by the structure transformation of 4-aminophenol in the basic condition and the property of substituted group on phenyl ring.The title compound was confirmed by IR,1H NMR and MS.

关 键 词：甘草次酸 酰胺衍生物 反应机理 

分 类 号：O657.61[理学—分析化学]