2,6-二甲酸-4-氯吡啶合成工艺改进及结构表征  

Improvement of Synthetic Process and Structural Characterization for 4-Chloropyridine-2,6-Dicarboxylic Acid

作　　者：吴晓琼[1] 傅志贤[2] 

机构地区：[1]南京化工职业技术学院应用化学系,南京市葛关路625号210048 [2]东南大学成贤学院,南京市东大路6号210088

出　　处：《光谱实验室》2011年第5期2507-2510,共4页Chinese Journal of Spectroscopy Laboratory

摘　　要：合成2,6-二甲酸-4-氯吡啶并进行工艺改进。以草酸二乙酯为起始原料,经克莱森缩合、氨化、氯化反应得到2,6-二甲酸-4-氯吡啶。所得产物经红外、核磁图谱确证,总收率38%。改进后的工艺,反应条件温和,适合工业化生产。The synthetic process of 4-chloropyridine-2,6-dicarboxylic acid was improved.4-chloropyridine-2,6-dicarboxylic acid was synthesized from ethyl oxalate by Claisen＇s condensation,followed by ammonification and chlorization.The structure of 4-chloropyridine-2,6-dicarboxylic acid was confirmed by IR and 1H NMR,and the overall yield was 38%.The synthetic process is practical and easy to be produced for industrialization.

关 键 词：草酸二乙酯 2 6-二甲酸-4-氯吡啶 结构表征 

分 类 号：O657.33[理学—分析化学] O657.2[理学—化学]