普伐他汀联合非洛地平治疗老年单纯收缩期高血压病临床疗效观察  

PRAVASTATIN COMBINED FELODIPINE THERAPY ISOLATED SYSTOLIC HYPERTENSION IN THE ELDERLY:A CLINICAL OBSERVATION

作　　者：林道德[1] 

机构地区：[1]海南省文昌市人民医院内科,文昌571300

出　　处：《现代预防医学》2011年第18期3800-3801,共2页Modern Preventive Medicine

摘　　要：[目的]观察普伐他汀联合非洛地平治疗老年单纯收缩期高血压病的临床效果。[方法]86例老年单纯收缩期高血压患者随机分为观察组和对照组各43例,两组均口服非洛地平缓释片5mg,每日1次;治疗组在此基础上每晚口服普伐他汀20mg,如2周内血压未达标,将非洛地平缓释片剂量调整为10mg/次。两组连续治疗6个月,检查及记录2组血压、脉压差及TC的变化。[结果]2组治疗前各项指标均无统计学差异。治疗后,2组间舒张压无统计学差异,而与对照组比较,治疗组收缩压、脉压差、总胆固醇有显著下降(P﹤0.05)。治疗组未见肌痛、肌炎、ALT升高、肌酸激酶升高等不良反应。[结论]普伐他汀与非洛地平缓释片联合治疗,能有效降低老年单纯收缩期高血压患者的血压及脉压差,安全性良好,值得临床推广应用。[Objective]To observe the clinic efficacy of pravastatin combined with felodipine therapy isolated systolic hypertension in the elderly.[Methods]86 cases of elderly patients with isolated systolic hypertension randomly divided into observation and control groups,each group had 43 cases,both groups got released felodipine Tablet for oral administration 5mg,1 times a day;Treatment group also got Pravastatin 20mg every night.If the blood pressure could not attend the standard in 2 weeks,we adjusted the dosage to 10mg/-released felodipine tablet.Two groups got treatment for 6 months,and we check and record changes in blood pressure,pulse pressure and TC in the 2 groups.[Results]There was no significant difference in the indexes before treatment in the 2 groups.After treatment,diastolic pressure did not show significant difference between the 2 groups.Compared with control group,systolic blood pressure,pulse pressure,total cholesterol has dropped significantly in the treatment group（P﹤0.05）.Treatment group did not see muscle pain,muscle inflammation,elevated ALT,elevated creatine kinase and other adverse effects.[Conclusion]Pravastatin-released felodipine tablet is effective in reducing blood pressure in elderly patients with isolated systolic hypertension and pulse pressure,which is security good and worthy of clinical application.

关 键 词：老年单纯收缩期高血压 普伐他汀 非洛地平 脉压差 

分 类 号：R544.1[医药卫生—心血管疾病]