系统性红斑狼疮患者血清IL-10和IL-18的检测及意义  

Detection and clinical significance of serum interleukin-10 and interleukin-18 in patients with systemic lupus erythematosus

作　　者：吴瑾滨[1] 周厚清[1] 李卓成[1] 徐磊[1] 

机构地区：[1]深圳市第二人民医院检验科,广东深圳518035

出　　处：《热带医学杂志》2011年第8期944-945,975,共3页Journal of Tropical Medicine

摘　　要：目的探讨系统性红斑狼疮(SLE)患者血清IL-10和IL-18的表达及其与疾病活动的关系。方法应用ELISA法检测104例SLE患者和100例健康体检者血清IL-10和IL-18的水平,其中SLE患者根据疾病活动性指数(SLEDAI)评分标准分为活动组(56例)和缓解组(48例),比较各组结果的差异,并分析SLEDAI与IL-10和IL-18的相关性。结果 SLE组IL-10和IL-18水平分别为(18.25±3.66)、(582.61±65.28)pg/ml,明显高于对照组的(7.12±2.36)、(186.24±60.39)pg/ml,差异有统计学意义(P<0.01);SLE活动组IL-10和IL-18水平分别为(25.98±4.75)、(683.72±62.48)pg/ml,高于缓解组的(14.67±3.21)、(493.51±69.17)pg/ml,差异亦有统计学意义(P<0.01);SLE患者血清IL-10和IL-18水平与SLEDAI呈正相关(P<0.05)。结论 IL-10和IL-18在SLE发病机制中发挥重要作用,而且与疾病活动性相关。Objective To investigate the expressions level of IL-10 and IL-18 in patients with systemic lupus erythematosus （SLE） and their correlation with the disease activity.Methods Enzyme linked immunosorbent assay （ELISA） was used to measure the levels of serum IL-10 and IL-18 from 104 SLE patients and 100 healthy persons.The patients were divided into the active group（56 patients） and the remission group （48 patients） by the SLE disease activity index （SLEDAI）.The correlation between SLEDAI and IL-10/IL-18 was analyzed.Results The levels of IL-10 and IL-18 in the SLE group were significantly higher than the healthy control group （P0.01）.The levels of IL-10 and IL-18 in the active group was significantly different from the remission group（P0.01）.The levels of IL-10 and IL-18 were significantly correlated with SLEDAI（P0.05）.Conclusion IL-10 and IL-18 play an important role in the pathogenesis of SLE,and their expression levels are correlated with the disease activity.

关 键 词：系统性红斑狼疮 IL-10 IL-18 疾病活动性 SLE疾病活动性指数 

分 类 号：R593.241[医药卫生—内科学]