Musashi-1基因启动子区域-2297T>C多态与人群食管癌的易感性  

Correlation between Musashi-1 gene -2297T > C polymorphism and risk of esophageal carcinoma in Southern Chinese population

作　　者：刘琳[1] 杨磊[1] 赵建伟[1] 黎银燕[1] 曾波航[1] 张鑫[1] Xiaoyang Wang 吕嘉春[1] 

机构地区：[1]广州医学院化学致癌研究所/呼吸疾病国家重点实验室,广东广州510182 [2]National Cancer Institute, National Institutes of Health, USA Bethesda, MD 20592

出　　处：《广州医学院学报》2011年第2期5-9,共5页Academic Journal of Guangzhou Medical College

基　　金：国家自然科学基金项目(81072366;30872142;30872178);广东省自然基金项目(8251018201000005);广东省高等学校高层次人才项目(2010-79)

摘　　要：目的:研究Musashi-1基因(MSI-1)启动子区-2297T>C(rs3742038)多态与我国人群食管癌发病的关联。方法:应用病例对照研究方法,采用Taqman技术检测300对食管癌病例的基因与正常对照-2297 T>C多态位点的基因型,并用SAS9.13软件分析该位点变异与食管癌易感性的关联。结果:以-2297TT基因型携带者为参照,携带C变异基因型(-2297CT/CC)个体发生食管癌的风险将显著增加(adjusted OR=2.27;95%CI=1.29-4.02),且随着变异等位基因个数增加,食管癌发病风险呈剂量—效应关系地增加(P_(trend)=0.0088)。结论:MSI-1基因启动子区-2297T>C基因变异型能显著增加我国人群发生食管癌的风险性,将为食管癌高危人群的筛选提供重要的遗传标志。Objective：To investigate the correlation between Musashi-1 （ MSI-1 ） gene promoter -2297T 〉 C （rs3742038） polymorphism and risk of esophageal carcinoma in Southern Chinese population. Methods：In a case-control study, the genotypes of-2297 T 〉 C polymorphism were studied by Taqman among 300 patients with esophageal carcinoma and 300 age- and sex frequency-matched cancer-free controls. SAS 9. 13 was used to analyze the correlation between this polymorphism and risk of esophageal carcinoma. Results ： Compared with the- 2297 TY genotype carriers, the variant genotypes -2297CT/CC carriers had an increased risk of esophageal carcinoma（ adjusted OR = 2.29 ;95% CI = 1.29-4. 18 ）. The risk of esophageal carcinoma increased along with the number of variant alleles in a dose-effect relationship（ Ptrend = 0.0008 ）. Conclusion：The variant genotypes （-2297CT/CC） in promoter region of MSI-1 gene are associated with an increased risk of esophageal carcinoma in Southern Chinese population, which can be used as a biomarker in screening of high risk population for esophageal carcinoma.

关 键 词：食管癌 Musashi-1基因 单核苷酸多态 

分 类 号：R188[医药卫生—流行病学]