海洛因成瘾者停止吸毒后的脑功能变化(英文)  

Brain function of heroin addicts after withdrawal

作　　者：王绪轶[1] 周旭辉[2] 廖艳辉[1] 唐劲松[1] 刘铁桥[1] 郝伟[1] 

机构地区：[1]中南大学湘雅二医院精神卫生研究所,长沙410011 [2]湖南省脑科医院成瘾科,长沙410007

出　　处：《中南大学学报（医学版）》2011年第8期733-738,共6页Journal of Central South University ：Medical Science

基　　金：supported by the National Key Basic Research and Development Program(NKBRDP)of China(2009CB522000);the National Natural Science Foundation(30971050);Doctoral Fund for New Teacher Project of Ministry of Education of China(20070533068)

摘　　要：目的:探讨海洛因成瘾者在戒断期的脑功能的变化。方法:用功能磁共振检测15位海洛因成瘾者停止吸毒3d和1个月的静息状态下脑功能情况,并与16位正常对照者进行比较。结果:海洛因成瘾者在停止吸毒3d后功能磁共振成像显示其额叶出现血氧水平依赖(blood oxygen level dependent,BOLD)信号增加;而停止吸毒1个月后,BOLD信号的增加恢复正常。结论:海洛因成瘾者戒断后仍有脑功能的异常,其中部分异常可以随着戒断时间的延长而恢复。Objective To explore what brain regions are modulated by heroin addiction and withdrawal.Methods We used functional magnetic resonance imaging to investigate the brain function in 15 heroin-dependent patients 3 days （acute） and 1 month （protracted） after heroin abstinence.Sixteen normal controls were included.Results The blood oxygen level-dependent signal in the orbitofrontal cortex of the brain of heroin-dependent patients was significantly elevated 3 days after the withdrawal.Hyperfunction of the orbitofrontal cortex declined 1 month after the withdrawal.Conclusion Heroin-dependent subjects at both 3 days and 1 month abstinence have persistent abnormalities in the brain function.Although some tangible beneficial effects are noted following 1 month of detoxification,possible permanent damage to the brain caused by heroin use is suggested.

关 键 词：海洛因 戒断 功能性磁共振成像 血氧水平依赖 

分 类 号：R445.2[医药卫生—影像医学与核医学]