TAO眼眶成纤维细胞上CCR1的表达  

Expression of CCR1 in the Orbital Fibroblasts with Thyroid Associated Ophthalmopathy

作　　者：刘春玲[1] 张学进[1] 郭波[1] 杨俊峰[1] 罗清礼[1] 

机构地区：[1]四川大学华西医院眼科,成都610041

出　　处：《四川大学学报（医学版）》2011年第5期630-632,共3页Journal of Sichuan University(Medical Sciences)

基　　金：国家自然科学基金(批准号30371518);四川省科技厅科技支撑项目(项目编号2009JY0007-1)资助

摘　　要：目的研究趋化因子受体CCR1在甲状腺相关眼病(thyroid associated ophthalmopathy,TAO)的眼眶成纤维细胞(orbital fibroblasts,OFs)上的表达,探讨其在发病机制中的作用。方法采用免疫组织化学SP法检测25例TAO患者和10例正常对照的眼眶组织中OFs上CCR1的表达情况,并将CCR1表达水平与TAO患者的临床活动性评分(clinical activity scores,GAS)进行相关性分析。结果 TAO患者的OFs明显表达CCR1,CCR1的表达阳性率为72%,正常人的OFs表达CCR1不明显或呈弱阳性,差异具有统计学意义(P<0.05)。TAO患者OFs上CCR1的表达与GAS无明显相关关系(r=0.048,P>0.05)。结论趋化因子受体CCR1可表达于TAO的OFs上,其在TAO的发病机制中可能发挥重要作用。Objective To investigate the expression of chemokine receptor（CCR1） in the orbital fibroblasts（OFs） with thyroid associated ophthalmopathy（TAO） and to explore the pathogenesis of TAO.Methods By immunohistochemistry,the expression of CCR1 was studied in 25 cases of TAO patientsand 10 normal control subjects and the correlation between CCR1 and GAS was analysed.Results The expression of CCR1 in the OFs with TAO was positive,but it was negative or weak positive in normal control subjects.The difference between them was significant（P0.05）.And the expression of CCR1 in the OFs with TAO had no significant correlation with GAS（r=0.048,P0.05）.Conclusion The expression of chemokine receptor CCR1 is higher on OFs of TAO patients than that of normal subjects.CCR1 maybe play a role in pathogenesis of TAO.

关 键 词：CCR1 甲状腺相关眼病 发病机制 成纤维细胞 免疫组化 

分 类 号：R581.1[医药卫生—内分泌] R771.3[医药卫生—内科学]