早期高负荷剂量氯吡格雷治疗急性冠脉综合征  

Clinical research of early high-loading-dose clopidogrel in treatment of patients with acute coronary syn-drome

作　　者：李金梁[1,3] 杨兆颖[1,2] 王嵬民[1,2] 孔俭[3] 

机构地区：[1]黑龙江省医院心血管内科,黑龙江省哈尔滨150036 [2]老年心血管内科 [3]吉林大学第一医院干部病房

出　　处：《中国基层医药》2011年第20期2747-2748,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨早期高负荷剂量氯吡格雷治疗对急性冠脉综合征（ACS）预后的影响及其安全性。方法将未进行冠脉介入治疗的急性冠脉综合征患者178例随机分为高负荷剂量用药组和对照组。高负荷剂量用药组96例于人院明确诊断后立即开始服用氯吡格雷600mg，后以75mg／d维持，而对照组82例患者则给予氯吡格雷300mg口服，随即75mg／d。比较两组1年之后主要心血管不良事件（心源性死亡、再次心肌梗死、再发心绞痛、继发心力衰竭及再次人院治疗）的发生率并判断其安全性。结果与对照组相比，高负荷剂量用药组患者主要心血管不良事件的发生率均显著下降（均P〈0．05）。两组均无主要和次要出血事件发生。结论早期高负荷剂量氯吡格雷治疗ACS可显著改善其预后，且安全耐受性好。Objective To observe the effects and safety of early high-loading-dose elopidogrel in treatment of patients with acute coronary syndrome. Methods 178 patients with STEMI were divided into two groups randomly. 96 patients were treated with clopidogrel 600 mg immediately when they came to the hospital, and then were treated with clopidogrel 75rag daily for 1 year;82 patients were treated with clopidogrel 300mg immediately when they came to the hospital, and then were treated with clopidogrel 75mg daily for 1 year. The attacks of postinfarction angina pectoris, e- vents of heart failure and the composite of death, reinfaretion or stroke were observed. Results Compared with control group, the high-loading-dose group had obvious reduction in the attacks of postinfaretion angina pectoris and the com- posite of death, reinfarction or stroke （ all P 〈 0. 05 ）. There were no major and minor bleeding events in the two groups. Conclusion Early treatment with high-loading-dose of clopidogrel in ACS could significantly improve its prognosis, and was safe and well tole.rated.

关 键 词：急性冠脉综合征 高负荷剂量 氯吡格雷 

分 类 号：R541[医药卫生—心血管疾病]