银杏达莫联合甲钴胺治疗糖尿病周围神经病变  

Case - control study on ginkgo - dipyridimolum and mecobalamln for treatment diabetic peripheral neuropathyCHEN

作　　者：陈金锋[1] 王学琴[1] 苏建彬[1] 徐峰[1] 

机构地区：[1]南通市第一人民医院内分泌科,江苏省南通226001

出　　处：《中国基层医药》2011年第20期2764-2765,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：观察银杏达莫联合甲钴胺治疗糖尿病周围神经病变（DPN）的临床疗效。方法对102例DPN患者进行随机对照观察，治疗组50例，对照组52例。治疗组予以银杏达莫和甲钴胺治疗，对照组单用甲钴胺治疗，连用4周。观察两组患者治疗前后症状和体征变化，检测正中神经、尺神经及腓神经的运动神经传导速度（MNCV）和感觉神经传导速度（SNCV）。结果治疗组的DPN症状、体征较对照组明显改善（x。=10．090，P〈0．01），治疗组治疗后正中神经、尺神经及腓神经的MNCV分别为（49．12±3．32）m／s、（52．1I±3．12）rrds、（47．32±3．21）m／s，较对照组有显著改善（t=3．517、13．204、3．968，均P〈O．05）；正中神经、尺神经及腓神经的SNCV分别为（47．13±2．56）m／s、（55．12±2．31）m／s、（46．78±2．66）m／s，较对照组有显著改善（t=3．653、17．990、4．348，均P〈0．05）。结论银杏达莫联合甲钴胺治疗DPN，疗效优于单用甲钴胺，且安全有效，值得临床推广。To observe the effect of the combined therapy of ginkgo-dipyridimolum and mecobal- mmn for diabetic peripheral neuropathy （DPN）. Methods A total of 102 DPN cases were randomly divided into treatment group（ n = 50） and control group（ n = 52）. The treatment group was given ginkgo-dipyridimolum and meco- balamin, and the control group was given only mecobalamin for 4 weeks. We observed the change of symptom and sign of both groups before and after treatment,and the MNCV and SNCV of median nerve,ulnar nerve and peroneal nerve were detected. Results In the treatment group, the improvement of DPN symptoms （X^2 = 10. 090, P 〈 0. 01 ） and nervous conducting speed were much more obvious that that in the control group（ MNCV of median nerve, ulnar nerve and peroneal nerve was （49.12 ±3.32） m/s, （ 52.11 ± 3.12） m/s and （ 47.32 ± 3.21 ） m/s respectively; SNCV of me- dian nerve,ulnar nerve and peroneal nerve was（47.13± 2.56 ）m/s, （55.12 ± 2.31 ）m/s, （,16.78± 2.66 ）m/s re- spectively, all P 〈 0.05）. Conclusion The combined therapy of ginkgo-dipyridimolum and mecobalamin could effec- tively improve the therapeutic outcome of DPN, and the treatment was safe and worthy of widespread use.

关 键 词：糖尿病 周围神经病变 银杏达莫 甲钴胺 

分 类 号：R587[医药卫生—内分泌]