二苯乙烯苷对实验性糖尿病大鼠心肌保护作用研究  

Protective effect of tetrahydroxystilbene glucoside on experimental diabetic cardiomyopathy in rats

作　　者：甘受益 陈勇 黄俊 李彩蓉[1,2] 蔡飞[3] 

机构地区：[1]咸宁市中心医院心血管内科 [2]咸宁学院临床医学院内科教研室 [3]咸宁学院药学院药理教研室,咸宁437100

出　　处：《中药药理与临床》2011年第4期13-15,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：湖北省教育厅中青年科研项目;编号:Q20112803

摘　　要：目的:探讨二苯乙烯苷(TSG)对糖尿病大鼠心功能、心室重塑、血浆心钠素(ANP)、血管紧张素AⅠ、血管紧张素AⅡ水平的影响。方法:将W ister大鼠分为正常对照组,糖尿病高脂饮食组,糖尿病高脂饮食+二苯乙烯苷小剂量(10 mg/kg.d)干预组,糖尿病高脂饮食+二苯乙烯苷大剂量(20 mg/kg.d)干预组。16周后,用超声心动图观察心功能,放射免疫法测定血浆ANP、血管紧张素AⅠ、血管紧张素AⅡ的水平。结果:二苯乙烯苷可改善糖尿病大鼠心功能及心室重塑指标,降低ANP、血管紧张素AⅠ、血管紧张素AⅡ水平,减轻心肌负荷。结论:二苯乙烯苷对糖尿病大鼠心肌微血管病变有一定的防治作用。Objective：To study the preventive effect of tetrahydroxystilbene glucoside（TSG）on cardiac function,ventricular remodeling and atrial natriuretic factor（ANP）,angiotensinⅠ,angiotensinⅡcontent in experimental diabetes rats.Methods： Male Wistar rats were divided into 4 group： normal control（n=10）,diabetic rats with high-fat diet（n=10）,diabetic rats with high-fat diet plus TSG（10 mg/kg·d,n=10）,diabetic rats with high-fat diet plus TSG（20 mg/kg·d,n=10）.All the rats were feed for 12 weeks,Doppler echocardiography was adopted to determine the cardiac function,and the ANP,angiotensinⅠ,angiotensinⅡin serum was assayed by radio-immunoassy.Results： TSG improved the parameters of cardiac function and ventricular remodeling in diabetes（P〈0.05）.Compared with diabetic rats with high-fat diet group,TSG decreased significantly serum ANP,angiotensinⅠ,angiotensinⅡcontent.Concluse： TSG has preventive effect on myocardiopathy in experimental diabetic rats.

关 键 词：二苯乙烯苷 糖尿病 心室重塑 心钠素 血管紧张素A Ⅰ 血管紧张素AⅡ 

分 类 号：R285[医药卫生—中药学]