动脉弹性指数与老年人冠状动脉粥样硬化的相关性研究  

Correlation between arterial compliance and elderly coronary atherosclerosis

作　　者：沈琳[1] 高海青[1] 由倍安[1] 邱洁[1] 

机构地区：[1]山东大学齐鲁医院老年病科,山东省心血管病蛋白组学重点实验室,济南250012

出　　处：《中华老年医学杂志》2011年第9期722-725,共4页Chinese Journal of Geriatrics

摘　　要：目的观察老年冠状动脉粥样硬化患者和冠心病患者大动脉弹性指数（C1）和小动脉弹性指数（C2）的变化，探讨C1、C2与老年冠状动脉粥样硬化狭窄病变Gensini积分的相关性。方法入选160例行选择性冠状动脉造影的老年患者，分为3组：冠状动脉正常组（正常组）、冠状动脉粥样硬化组（硬化组）和冠心病组。应用桡动脉舒张期脉搏波形分析仪测定入选者的动脉弹性，得到C1和C2；冠状动脉造影后对所有入选者的冠状动脉狭窄病变程度应用Gensini积分法进行定量评定；分别对硬化组和冠心病组的C1、C2与Gensini积分间的相关性进行直线相关分析。结果硬化组的C2低于正常组（P〈0．01），冠心病组的C2低于硬化组（P〈0．05），3组间的C1比较，差异无统计学意义；硬化组和冠心病组患者Gensini积分分别为（5．4士2．6）分与（51．3±32．1）分，两组比较差异有统计学意义（t=10．574，P〈0．01）；冠状动脉狭窄病变Gensini积分均与C2呈负相关，与C1无相关性。结论在老年冠状动脉粥样硬化这一亚临床阶段，C2已开始下降，并随着冠状动脉粥样硬化病变程度的加重而降低，测定C2有助于老年冠状动脉粥样硬化患者的早期发现。Objective To investigate the changes of capacitive arterial compliance（C1） and oscillatory arterial compliance （C2） in elderly patients with the coronary atherosclerosis and the coronary heart disease （CHD）and to study the association between Gensini Score and C1 or C2. Methods Elderly subjects （160 cases） were divided into three groups according to the results of selective coronary angiography： the normal,the coronary atherosclerosis and the CHD group. C1 and C2 were measured using a DO-2020 cardiovascular profiling instrument. The stenosis severity of coronary artery diseases was assessed using a scoring system called Gensini score. Bivariate analyses were performed to study the association between Gensini Score of coronary artery and each of C1 and C2. Results C2 in the coronary atherosclerosis group was significantly lower than that in the normal group, and higher than in CHD group. C1 had no statistically difference among the three groups. Gensini integral in the coronary atherosclerosis versus the CHD groups were （5.4＋2.6） vs. （51.3＋32.1）, respectively （t= 10. 574, P〈0.01）. Gensini Score in the coronary atherosclerosis group had no relation with C1, and was negtively correlated with C2. Conclusions C2 is decreased in the early stages of the coronary artery atherosclerosis in elderly patients, and may help the identification of early coronary atherosclerosis.

关 键 词：冠状动脉疾病 小动脉硬化 冠状血管造影术 

分 类 号：R541.4[医药卫生—心血管疾病]