NF-κB和VEGF在不同宫颈病变组织中的表达及其意义  

The expression and its significance of NF - K B and VEGF in different cervical le- sions

作　　者：杨树艳[1] 

机构地区：[1]哈尔滨医科大学第四附属医院妇产科,黑龙江哈尔滨150086

出　　处：《中国妇幼保健》2011年第26期4085-4087,共3页Maternal and Child Health Care of China

基　　金：黑龙江省教育厅科学技术项目[11551305]

摘　　要：目的：通过比较慢性宫颈炎,CINⅠ、CINⅡ、CINⅢ和宫颈鳞癌中NF-κB与VEGF的表达情况,探讨NF-κB与VEGF在宫颈癌发生发展中的作用及相互之间的关系。方法：采用免疫组织化学法（SP法）检测NF-κB以及VEGF在15例慢性宫颈炎,42例宫颈上皮内瘤样病变（CIN）和51例宫颈鳞癌SCCs的表达。结果：免疫组织化学结果显示,在炎症组、CINⅠ-Ⅱ,CINⅢ和宫颈鳞癌中NF-κB与VEGF的组织学评分呈逐级递增关系。在宫颈鳞癌中NF-κB、VEGF表达强度与病理分型无关,而与病理分级及淋巴结转移有关,且随病理分级的增高NF-κB与VEGF的组织学评分呈逐级递增关系。而淋巴结转移（＋）组与淋巴结转移（-）组之间比较有统计学差异（P〈0.01）。结论：NF-κB的异常激活是促进宫颈癌发生发展的重要因素,NF-κB还可能通过上调VEGF表达而促进肿瘤的血管生成来促进癌症发生及淋巴结转移。Objective：To explore clinical significance and relation between NF-κB and the expression VEGF in the progression of cervical carcinoma. Methods：15 cases of chronic cervicitis,42cases of CIN and 51 cases of cervical squamous cell carcinoma.were chose,NF-κB and VEGF of these tissues were examined with immunohistochemistry. Results：NF-κB and VEGF were expressed in all the types of tissue.The expression rate decreased gradually.The expressions of NF-κB and VEGF correlated with pathologicalgrades well or lymph node translation（P〈0.01）,but not with pathological type（P〉0.05）.The expression of NF-κB and VEGF was positively correlated with the pathologic grade.There were significant differences of both NF-κB and VEGF between the lymph node metastasis and without metastasis（P〈0.01）. Conclusion：The high-expression of NF-κB and VEGF protein might play an important role in tumor genesis and the development of cervical squamous carcinoma.

关 键 词：NF-ΚB VEGF 宫颈上皮内瘤样病变 宫颈鳞癌 免疫组织化学 

分 类 号：R711.74[医药卫生—妇产科学]