盐酸氨基葡萄糖胶囊治疗膝骨关节炎疗效观察  

Effect of Glucosamine Hydrochloride Capsules in the Treatment of Knee Osteoarthritis

作　　者：赵延斌[1] 林伍伍[2] 

机构地区：[1]广西壮族自治区南溪山医院药剂科,广西桂林541002 [2]广西壮族自治区南溪山医院中医骨科,广西桂林541002

出　　处：《中国药师》2011年第9期1314-1315,共2页China Pharmacist

摘　　要：目的:观察比较盐酸氨基葡萄糖胶囊和美洛昔康胶囊治疗膝骨关节炎的临床疗效及不良反应方法:103例膝骨关节炎患者随机分为观察组(n=51)和对照组(n=52),分别给予盐酸氨基葡萄糖胶囊和美罗昔康胶囊治疗6周,比较两组临床疗效。结果:两组患者临床症状均改善,总有效率分别为47.06%、42.31%(P>0.05),不良反应发生率分别为3.92%、17.31%(P<0.01)。结论:盐酸氨基葡萄糖胶囊和美洛昔康胶囊均为治疗骨性关节炎的有效药物,盐酸氨基葡萄糖胶囊的不良反应更少,值得临床推广应用。Objective： To observe the effect and adverse drug reactions of glucosamine hydrochloride capsules and meloxicom capsules in the treatment of knee osteoarthritis. Method： 103 patients with knee osteoarthritis were randomly assigned to receive oral glucosamine hydrochloride capsules （ observation group, n = 51 ） or meloxicom capsules （ control group, n = 52） treatment for 6 weeks. Effect of the two groups were observed. Result： After 6 weeks treatment, the clinical symptoms of the patients all improved. The total effective rate of the observation group and control group was 47.06% and 42. 31% , respectively （P 〉 0. 05 ） and incidence rate of the adverse drug reactions was 3.92% and 17.31%, respectively （ P 〈 0. 01 ）. Conclusion： Glucosamine hydrochloride capsules and meloxicom capsules are both the effective drugs for knee osteoarthritis treatment, and the incidence rate of adverse drug reactions of glucosamine hydrochloride capsules is lower than that of meloxicom capsules which is worthy of clinical application.

关 键 词：盐酸氨基葡萄糖胶囊 美洛昔康胶囊 膝骨性关节炎 

分 类 号：R977.6[医药卫生—药品]