乙型肝炎病毒基因型的临床意义  

Hepatitis B Virus Genotype and Its Clinical Significance

作　　者：古巧燕[1] 任迎全[1] 

机构地区：[1]延安大学附属医院感染科,陕西延安716000

出　　处：《医学综述》2011年第18期2735-2737,共3页Medical Recapitulate

摘　　要：乙型肝炎病毒的基因分型对乙型肝炎病毒感染的临床有独特的意义,在致病力方面:D基因型较A基因型的致病力强,预后差,C基因型较B基因型的致病力强,预后差。在治疗方面:C基因型干扰素抗病毒疗效优于B基因型,A基因型干扰素抗病毒疗效优于D基因型;A、B基因型拉米夫定抗病毒疗效优于D、E、C基因型等。可见乙型肝炎病毒的基因分型与乙型肝炎病毒感染的临床密切相关。The genotype of hepatitis B virus has a unique significance in controlling hepatitis B virus effectively.For example,in pathogenicity：genotype D is more virulent and has poorer prognosis than genotype A,genotype C is more virulent and has poorer prognosis than genotype B;in terms of treatment：genotype C interferon antiviral effect is better than that of genotype B,genotype A interferon antiviral effect is better than that of genotype D;lamivudine antiviral efficacy on genotype A,B is superior to genotype D,E,C.It can be seen that the genotypes of hepatitis B virus is closely related to the clinical practice of hepatitis B virus infection.

关 键 词：乙型肝炎病毒 基因型 临床意义 

分 类 号：R512.62[医药卫生—内科学]