维生素D的骨外作用研究进展  

Advances in Research on Non- skeletal Actions of Vitamin D

作　　者：张俊防[1] 彭若宇[1] 

机构地区：[1]南方医科大学第三附属医院体检中心内科,中国广州510630

出　　处：《国际老年医学杂志》2011年第5期226-230,共5页International Journal of Geriatrics

摘　　要：随着对维生素D研究的深入，发现它不仅有传统的对钙磷和骨代谢的重要作用，而且对骨外系统，包括心血管系统、糖代谢、免疫系统及细胞增殖和分化等都有密切关系。维生素D可以下调肾素-血管紧张素-醛固酮系统活性，抑制心肌肥厚及心肌功能失调，抑制炎症介导的动脉粥样硬化及血管舒张功能受损；影响胰腺B细胞胰岛素分泌及胰岛素抵抗；调控细胞生长、促进细胞分化及抑制细胞增殖；调节人体的固有免疫和后天获得性免疫。从而影响心血管系统疾病、2型糖尿病、肿瘤及免疫系统疾病等发生和发展。With the advances in research on vitamin D （VD） it is found that VD has an important effect not only in traditional metabolism of calcium and phosphorus but also in non - skeletal system including cardiovascular system, glucose metabolism, the immune system and cell proliferation and differentiation. It can downregulate the renin - angiotensin - aldosterone system, supress cardiac hypertrophy and myocardial dysfunction, keep down inflammation - mediated atherosclerosis and diastolic dysfunction, and have an effect on the synthesis and secretion of insulin from B cell and insulin resistance. It can also regulate cell growth and differentiation and inhibit cell proliferation. And then it affects the occurrence and development of the cardiovascular system disease, type 2 diabetes, cancer and immune system disease.

关 键 词：维生素D 心血管系统 2型糖尿病 肿瘤 免疫系统 

分 类 号：R681[医药卫生—骨科学]