取代苯甲酰胺基硫代甲酸-(5-取代苯基-2-呋喃)-甲酯的合成及杀菌活性  

Synthesis and Fungicidal Activities of Aryl Thiocarbamic Acid-5-aryl-2-furanmethyl Ester

作　　者：李映[1,2] 李宝聚[3] 杨新玲[1] 石延霞[3] 苗宏健[1] 凌云[1] 

机构地区：[1]中国农业大学理学院应用化学系农业部农药化学及应用重点开放实验室,北京100193 [2]山东农业大学化学与材料科学学院,泰安271018 [3]中国农业科学院蔬菜花卉研究所,北京100081

出　　处：《有机化学》2011年第9期1411-1418,共8页Chinese Journal of Organic Chemistry

基　　金：国家973计划(No.2010CB126104);国家自然科学基金(No.20872175);农业部农药化学与应用重点开放实验室课题(No.MOAPCA201010);绿色农药与生物工程教育部重点实验室开放课题(No.2008GDGP0101)资助项目

摘　　要：为了发现高效、低毒的农药先导化合物,以真菌几丁质为研究对象,以取代苯甲酸、5-取代苯基-2-呋喃甲醇为起始原料,设计合成了23个新型取代苯甲酰胺基硫代甲酸-(5-取代苯基-2-呋喃)-甲酯,其结构经IR,1H NMR和元素分析确证.初步生测结果表明,在50μg/mL浓度下,化合物对黄瓜褐斑菌、黄瓜灰霉菌、黄瓜枯萎菌表现出明显的防效,尤其对于黄瓜灰霉菌,大部分化合物的防效优于对照药剂40%菌核净WP.To find new pesticide lead compounds with high activity and low toxicity,chitin was chosen as the research target.23 novel aryl thiocarbamic acid-5-aryl-2-furanmethyl esters were designed and synthe-sized from substituted benzoic acid and 5-aryl-2-furanmethanol.Their structures were confirmed by IR,1H NMR and elemental analysis.The preliminary bioassay results indicated that some compounds showed obvious inhibition effects against Corynespora cassiicola,Botrytis cinereapers,Fusarium oxysporum,especially to Botrytis cinereapers in which most compounds showed higher inhibitory rate than control fungicide 40% WP dimethachlon.

关 键 词：苯甲酰脲 几丁质 苯甲酰胺基硫代甲酸-(5-取代苯基-2-呋喃)-甲酯 杀菌活性 

分 类 号：TQ450.1[化学工程—农药化工]